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p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization
Am J Physiol Cell Physiol. 2023 Apr 24. doi: 10.1152/ajpcell.00425.2022. Online ahead of print.ABSTRACTEndothelial cell (EC) migration is critical for the repair of monolayer disruption following angioplasties, but migration is inhibited by lipid oxidation products, including lysophosphatidylcholine (lysoPC), which open canonical transient receptor potential 6 (TRPC6) channels. TRPC6 activation requires an increase in intracellular Ca2+ concentration ([Ca2+]i), the source of which is unknown. LysoPC can activate phospholipase A2 to release arachidonic acid (ArA). ArA can activate arachidonic acid-regulated calcium (ARC) ch...
Source: American Journal of Physiology. Cell Physiology - April 24, 2023 Category: Cytology Authors: Pinaki Chaudhuri Priya Putta Michael A Rosenbaum Linda M Graham Source Type: research

Platelet-derived microvesicles induce calcium oscillations and promote VSMC migration via TRPV4
Conclusions: TRPV4 participated in the calcium oscillations and VSMC migration induced by PMVs. PMVs and the related molecules might be novel therapeutic targets for vascular remodeling during vascular injury.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Shan-Shan Li, Shuang Gao, Yi Chen, Han Bao, Zi-Tong Li, Qing-Ping Yao, Ji-Ting Liu, Yingxiao Wang, Ying-Xin Qi Tags: Research Paper Source Type: research