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Schisanhenol Attenuates OxLDL-Induced Endothelial Dysfunction via an AMPK-Dependent Mechanism
In this study, human umbilical vein endothelial cells (HUVECs) were pre-treated with SAL and oxLDL. Our results showed that adenosine monophosphate-activated protein kinase (AMPK) phosphorylation was enhanced in cells pre-treated with SAL in time-dependent and dose-dependent manners. Subsequently, oxLDL-induced AMPK dephosphorylation and protein kinase C (PKC) phosphorylation were significantly reversed in the presence of SAL. In addition, SAL treatment led to an inhibiting effect on the oxLDL-induced membrane assembly of NADPH oxidase subunits, and a similar effect was observed in ROS generation. This effect was further c...
Source: The American Journal of Chinese Medicine - July 30, 2023 Category: Complementary Medicine Authors: Tsan-Hung Chiu Chang-Wen Ku Tsung-Jung Ho Kun-Ling Tsai Wei-Ching Hsu Yu-An Chen Hsiu-Chung Ou Hsiu-I Chen Source Type: research

Synergistic effect of schizandrin A and DNase I knockdown on high glucose induced beta cell apoptosis by decreasing intracellular calcium concentration
CONCLUSION: Overall, our study reveals a synergistic effect of Sch A and DNase I knockdown in protecting β-cells from HG-induced apoptosis.PMID:37454250 | PMC:PMC10320450 | DOI:10.19852/j.cnki.jtcm.2023.04.003
Source: Journal of Traditional Chinese Medicine - July 16, 2023 Category: Complementary Medicine Authors: Zhu Bin Y U Ning Wang Lei Tian Yue W U Mingfen Zhao Zhigang Source Type: research

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