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CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D
CONCLUSIONS: CircPRKCI is significantly highly expressed in LUAD, and the highly expressed circPRKCI is capable of facilitating LUAD cell migration, proliferation and cycle. CircPRKCI may regulate the malignant phenotype of LUAD via the miR-219a-5p/CAMK1D axis.PMID:33660800 | DOI:10.26355/eurrev_202102_25085
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: M-H Sui W-W Zhang D-M Geng D-J Sun Source Type: research

Cancers, Vol. 12, Pages 218: Plasma Membrane Ca2+ ATPase Isoform 4 (PMCA4) Has an Important Role in Numerous Hallmarks of Pancreatic Cancer
I. E. Bruce Pancreatic ductal adenocarcinoma (PDAC) is largely resistant to standard treatments leading to poor patient survival. The expression of plasma membrane calcium ATPase-4 (PMCA4) is reported to modulate key cancer hallmarks including cell migration, growth, and apoptotic resistance. Data-mining revealed that PMCA4 was over-expressed in pancreatic ductal adenocarcinoma (PDAC) tumors which correlated with poor patient survival. Western blot and RT-qPCR revealed that MIA PaCa-2 cells almost exclusively express PMCA4 making these a suitable cellular model of PDAC with poor patient survival. Knockdown of PMCA4 in ...
Source: Cancers - January 15, 2020 Category: Cancer & Oncology Authors: Pishyaporn Sritangos Eduardo Pena Alarcon Andrew D. James Ahlam Sultan Daniel A. Richardson Jason I. E. Bruce Tags: Article Source Type: research

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