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In vitro effects of Harmine against Echinococcus granulosus protoscoleces by stimulating DNA damage
In this study, we aim to evaluate the anti-parasitic efficacy and the mechanism of DNA damage of HM against E. granulosus. In vitro, the results indicated that, within two and three days of treatment, ABZ killed 30.4% and 35.3% of protoscoleces, whereas HM killed 52.7% and 100% of protoscoleces, respectively. Furthermore, the presence of abnormalities in the internal structure of protoscoleces was examined by ultrastructural images of TEM, and the result showed that there were scattered nucleoli and heterochromatin margination phenomenon by HM treatment. DNA damage of protoscoleces was examined by using the comet assay, an...
Source: Experimental Parasitology - June 7, 2021 Category: Parasitology Authors: Shuai Lu Limei Wen Yuehong Gong Chunyan Tian Huijing Gao Bei Chen Guodong L ü Jun Zhao Jianhua Wang Source Type: research

In vitro effects of harmine against Echinococcus granulosus protoscoleces by stimulating DNA damage
In this study, we aim to evaluate the anti-parasitic efficacy and the mechanism of DNA damage of HM against E. granulosus. In vitro, the results indicated that, within two and three days of treatment, ABZ killed 30.4% and 35.3% of protoscoleces, whereas HM killed 52.7% and 100% of protoscoleces, respectively. Furthermore, the presence of abnormalities in the internal structure of protoscoleces was examined by ultrastructural images of TEM, and the result showed that there were scattered nucleoli and heterochromatin margination phenomenon by HM treatment. DNA damage of protoscoleces was examined by using the comet assay, an...
Source: Experimental Parasitology - June 7, 2021 Category: Parasitology Authors: Shuai Lu Limei Wen Yuehong Gong Chunyan Tian Huijing Gao Bei Chen Guodong L ü Jun Zhao Jianhua Wang Source Type: research