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The role of the TGF- β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children
CONCLUSION: SMAD2 and SMAD3 have a certain clinical relevance with hydatidosis in young children. The LIF expression level may be related to the cystic transformation of protoscoleces. It has been suggested that the TGF-β/Smads/LIF signaling pathway may be present in the process of protoscoleces cyst formation; this provides a research basis for the prevention and treatment of post-infection parasitism of E. multilocularis eggs in young children.PMID:36443650 | DOI:10.1186/s12860-022-00452-3
Source: Mol Biol Cell - November 28, 2022 Category: Molecular Biology Authors: Shuang-Li Qin Yun Guo Shui-Xue Li Ling Zhou Azguli Maimaiti Yusufu Akemu Jun He Hai-Xia Yao Source Type: research

In vitro effects of Harmine against Echinococcus granulosus protoscoleces by stimulating DNA damage
In this study, we aim to evaluate the anti-parasitic efficacy and the mechanism of DNA damage of HM against E. granulosus. In vitro, the results indicated that, within two and three days of treatment, ABZ killed 30.4% and 35.3% of protoscoleces, whereas HM killed 52.7% and 100% of protoscoleces, respectively. Furthermore, the presence of abnormalities in the internal structure of protoscoleces was examined by ultrastructural images of TEM, and the result showed that there were scattered nucleoli and heterochromatin margination phenomenon by HM treatment. DNA damage of protoscoleces was examined by using the comet assay, an...
Source: Experimental Parasitology - June 7, 2021 Category: Parasitology Authors: Shuai Lu Limei Wen Yuehong Gong Chunyan Tian Huijing Gao Bei Chen Guodong L ü Jun Zhao Jianhua Wang Source Type: research

In vitro effects of harmine against Echinococcus granulosus protoscoleces by stimulating DNA damage
In this study, we aim to evaluate the anti-parasitic efficacy and the mechanism of DNA damage of HM against E. granulosus. In vitro, the results indicated that, within two and three days of treatment, ABZ killed 30.4% and 35.3% of protoscoleces, whereas HM killed 52.7% and 100% of protoscoleces, respectively. Furthermore, the presence of abnormalities in the internal structure of protoscoleces was examined by ultrastructural images of TEM, and the result showed that there were scattered nucleoli and heterochromatin margination phenomenon by HM treatment. DNA damage of protoscoleces was examined by using the comet assay, an...
Source: Experimental Parasitology - June 7, 2021 Category: Parasitology Authors: Shuai Lu Limei Wen Yuehong Gong Chunyan Tian Huijing Gao Bei Chen Guodong L ü Jun Zhao Jianhua Wang Source Type: research

Molecular insights into a tetraspanin in the hydatid tapeworm Echinococcus granulosus
Conclusions: This is the first report characterizing a tetraspanin from the tapeworm E. granulosus. Our results suggest that Eg-TSP1 is associated with biogenesis of the tegument and maintenance of structural integrity of E. granulosus and could therefore be a candidate intervention target for control of hydatid disease.
Source: Parasites and Vectors - June 10, 2015 Category: Microbiology Authors: Dandan HuXingju SongYue XieXiuqin ZhongNing WangYu ZhengXiaobin GuTao WangXuerong PengGuangyou Yang Source Type: research