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Associations of DDX60L With the Clinical Features and Prognosis of Hepatocellular Carcinoma
ConclusionWe found that the downregulation of DDX60L expression correlated with poor prognosis in patients with HCC, which may be independent of the HCV-related pathway. Furthermore, DDX60L significantly inhibited the proliferation of Hep3B cells, migration and invasion of Hep3B and HCCLM3 cells. Therefore, DDX60L can serve as a prognostic biomarker and therapeutic target for HCC.
Source: Frontiers in Oncology - February 11, 2022 Category: Cancer & Oncology Source Type: research

The IL-6/STAT3 pathway upregulates microRNA-125b expression in hepatitis C virus infection.
Conclusions: This study elucidates a novel pathway for miR-125b in the pathogenesis of chronic HCV infection and suggests it as a possible target for treating HCV infection. PMID: 29541414 [PubMed]
Source: Oncotarget - March 16, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Abstract 3171: Overexpression of a cancer stem cell marker doublecortin-like kinase (DCLK1) leads to activation of inflammatory cascade during development of virus-induced hepatocellular carcinoma
Conclusions: DCLK1 overexpression appears to be intimately related to the activation of pro-inflammatory and MAPK signaling pathways during the development of virus-induced pre-neoplastic conditions and initiation of tumors in liver. Thus, targeting DCLK1 at early stage of liver diseases may prevent virus-induced cirrhosis and HCC. Citation Format: Naushad Ali, Parthasarathy Chandrakesan, Mark Huycke, Sanam Husain, Allison F. Gillaspy, Randal May, William L. Berry, Sripathi Sureban, Dongfeng Qu, Nathaniel Weygant, Michael S. Bronze, Danny N. Dhanasekaran, Courtney W. Houchen. Overexpression of a cancer stem cell marker dou...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Ali, N., Chandrakesan, P., Huycke, M., Husain, S., Gillaspy, A. F., May, R., Berry, W. L., Sureban, S., Qu, D., Weygant, N., Bronze, M. S., Dhanasekaran, D. N., Houchen, C. W. Tags: Carcinogenesis Source Type: research

High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential
In conclusion, high uMtCK expression in HCC may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator, and associated with highly malignant potential to suggest a poor prognosis. © 2013 UICC
Source: International Journal of Cancer - October 31, 2013 Category: Cancer & Oncology Authors: Baasanjav Uranbileg, Kenichiro Enooku, Yoko Soroida, Ryunosuke Ohkawa, Yotaro Kudo, Hayato Nakagawa, Ryosuke Tateishi, Haruhiko Yoshida, Seiko Shinzawa, Kyoji Moriya, Natsuko Ohtomo, Takako Nishikawa, Yukiko Inoue, Tomoaki Tomiya, Soichi Kojima, Tomokazu Tags: Early Detection and Diagnosis Source Type: research

High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly‐malignant potential
In conclusion, high uMtCK expression in HCC may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator, and associated with highly‐malignant potential to suggest a poor prognosis. © 2013 Wiley Periodicals, Inc.
Source: International Journal of Cancer - October 17, 2013 Category: Cancer & Oncology Authors: Baasanjav Uranbileg, Kenichiro Enooku, Yoko Soroida, Ryunosuke Ohkawa, Yotaro Kudo, Hayato Nakagawa, Ryosuke Tateishi, Haruhiko Yoshida, Seiko Shinzawa, Kyoji Moriya, Natsuko Ohtomo, Takako Nishikawa, Yukiko Inoue, Tomoaki Tomiya, Soichi Kojima, Tomokazu Tags: Early Detection and Diagnosis Source Type: research