• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Extracellular vesicles of Clonorchis sinensis promote IL-6 and TNF- α secretion via the Toll-like receptor 9-mediated ERK pathway in biliary epithelial cells
Dev Comp Immunol. 2022 Sep 29:104555. doi: 10.1016/j.dci.2022.104555. Online ahead of print.ABSTRACTClonorchis sinensis is closely associated with cholangitis, cholecystitis, biliary fibrosis and cholangiocarcinoma. The present study elucidated the role of extracellular vesicles of C. sinensis (CsEVs) in activating Toll-like receptor 9 (TLR9) and regulating inflammatory responses. The results showed that TLR9 expression was increased in the livers of C. sinensis-infected mice. CsEVs were cup-shaped or saucer-shaped and 80-120 nm in diameter. CsEVs activated TLR9 and promoted IL-6 and TNF-α expression in mouse biliary epit...
Source: Developmental and Comparative Immunology - October 2, 2022 Category: Allergy & Immunology Authors: Yuru Wang Xiaocen Wang Nan Zhang Yanhui Yu Penglin Bao Yeting Ma Haoyang Zhang Xu Zhang Xichen Zhang Pengtao Gong Xin Li Jianhua Li Source Type: research

MHP-1 inhibits cancer metastasis and restores topotecan sensitivity via regulating epithelial-mesenchymal transition and TGF-β signaling in human breast cancer cells
Conclusion MHP-1 significantly inhibited breast cancer metastasis and restored drug sensitivity in TPT-resistant cells via down-regulation of TGF-β signaling and EMT program. The combination of non-toxic agents like MHP-1 and current anti-cancer drugs should be considered in the future treatment of cancer. Graphical abstract
Source: Phytomedicine - July 4, 2016 Category: Drugs & Pharmacology Source Type: research