• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs
Humans can be infected by zoonotic avian, pandemic and seasonal influenza A viruses (IAVs), which differ by receptor specificity and conformational stability of their envelope glycoprotein hemagglutinin (HA). It was shown that receptor specificity of the HA determines the tropism of IAVs to human airway epithelial cells, the primary target of IAVs in humans. Less is known about potential effects of the HA properties on viral attachment, infection and activation of human immune cells. To address this question, we studied the infection of total human peripheral blood mononuclear cells (PBMCs) and subpopulations of human PBMC...
Source: Frontiers in Immunology - March 14, 2022 Category: Allergy & Immunology Source Type: research

Molecular identification of duck DDX3X and its potential role in response to Tembusu virus.
This study will contribute to a better understanding of duDDX3X in the innate immune system of ducks and lay a solid foundation for further studies of duDDX3X in antiviral immunity. PMID: 31899305 [PubMed - as supplied by publisher]
Source: Developmental and Comparative Immunology - December 29, 2019 Category: Allergy & Immunology Authors: Li N, Jiang S, Zhao J, Yang Y, Deng Kai, Wei L, Cai Y, Li B, Liu S Tags: Dev Comp Immunol Source Type: research