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Honokiol reduces fungal burden and ameliorate inflammation lesions of Aspergillus fumigatus keratitis via Dectin-2 down-regulation
CONCLUSIONS: Honokiol possesses anti-fungal and anti-inflammatory effects in Aspergillus fumigatus keratitis and may develop a potential and safe therapeutic modality for FK.PMID:36933490 | DOI:10.1016/j.intimp.2023.109849
Source: International Immunopharmacology - March 18, 2023 Category: Allergy & Immunology Authors: Lu Zhan Xue Tian Jing Lin Yingxue Zhang Hengrui Zheng Xudong Peng Guiqiu Zhao Source Type: research

Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis
CONCLUSION: DMF limits fungal growth by suppressing biofilm formation, conidial adherence and respiratory metabolism. It also exerts an anti-inflammatory effect on fungal keratitis by inhibiting pyroptosis, which could be regulated by Nrf2. Our results suggest that DMF plays a therapeutic role in fungal keratitis.PMID:36641891 | DOI:10.1016/j.intimp.2023.109721
Source: International Immunopharmacology - January 15, 2023 Category: Allergy & Immunology Authors: Lingwen Gu Jing Lin Qian Wang Lina Zhang Min Yin Hao Lin Hengrui Zheng Guiqiu Zhao Cui Li Source Type: research

Galectin-3 plays an important pro-inflammatory role in A. fumigatus keratitis by recruiting neutrophils and activating p38 in neutrophils
CONCLUSION: These data proved that A. fumigatus increased Gal-3 expression and elevated disease clinical scores, PMNs infiltration and cytokines expression through Gal-3. In PMNs, A. fumigatus upregulated IL-1β and IL-6 secretion through the Gal-3 / p38 pathway.PMID:33933850 | DOI:10.1016/j.intimp.2021.107706
Source: International Immunopharmacology - May 2, 2021 Category: Allergy & Immunology Authors: Yawen Niu Jing Lin Cui Li Xudong Peng Nan Jiang Qiang Xu Min Yin Hao Lin Lingwen Gu Guiqiu Zhao Source Type: research

HMGB1 mediates Aspergillus fumigatus-induced inflammatory response in alveolar macrophages of COPD mice via activating MyD88/NF- κB and syk/PI3K signalings.
In conclusion, HMGB1 is responsible for A. fumigatus-induced inflammatory response in COPD alveolar macrophage via Dectin-1 and TLR2/4 receptor through activating MyD88/NF-κB and syk/PI3K signalings. PMID: 29078091 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - October 24, 2017 Category: Allergy & Immunology Authors: Zhang P, Xin X, Fang L, Jiang H, Xu X, Su X, Shi Y Tags: Int Immunopharmacol Source Type: research

Dectin-1 is essential for IL-1 β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
CONCLUSIONS: Being an important inflammatory PRR to mediate host inflammatory response, Dectin-1 induced IL-1β production is JNK dependent in mouse A. fumigatus keratitis, and suppressed apoptosis mediated anti-inflammatory response. PMID: 28926773 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - September 16, 2017 Category: Allergy & Immunology Authors: Yuan K, Zhao G, Che C, Li C, Lin J, Zhu G, He K Tags: Int Immunopharmacol Source Type: research