Dectin-1 is essential for IL-1 β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.

CONCLUSIONS: Being an important inflammatory PRR to mediate host inflammatory response, Dectin-1 induced IL-1β production is JNK dependent in mouse A. fumigatus keratitis, and suppressed apoptosis mediated anti-inflammatory response.
PMID: 28926773 [PubMed - as supplied by publisher]

Source: International Immunopharmacology - September 16, 2017 Category: Allergy & Immunology Authors: Yuan K, Zhao G, Che C, Li C, Lin J, Zhu G, He K Tags: Int Immunopharmacol Source Type: research