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The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
In this study, we showed that the cGAS-STING signaling pathway was activated in human corneal epithelial cells (HCECs) and in mouse corneas infected with A. fumigatus. Knockdown of cGAS reduced A. fumigatus-induced production of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IFN-β. However, reconstruction of cGAS activity restored the inflammatory response in HCECs infected with A. fumigatus. A specific cGAS inhibitor, RU.521, could also significantly inhibit A. fumigatus-induced inflammatory cytokine expression. In addition, we found that cGAS was indispensable for the autophagy flux evoked by A. fumigat...
Source: Experimental Eye Research - November 20, 2020 Category: Opthalmology Authors: Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X Tags: Exp Eye Res Source Type: research

Aspergillus fumigatus promotes T helper type 2 responses through thymic stromal lymphopoietin production by human corneal epithelial cells
ConclusionThese findings suggested that HCEC‐derived TSLP has a key role in adaptive immune responses of fungal keratitis via skewing Th2 differentiation and promoting humoral immunity. This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Ophthalmology - January 13, 2016 Category: Opthalmology Authors: Luping Wang, Leyi Wang, Xinyi Wu Tags: Original Article Source Type: research