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High glucose induces HSP47 expression and promotes the secretion of inflammatory factors through the IRE1 α/XBP1/HIF-1α pathway in retinal Müller cells
Exp Ther Med. 2021 Dec;22(6):1411. doi: 10.3892/etm.2021.10847. Epub 2021 Oct 7.ABSTRACTDiabetic retinopathy, a common complication of diabetes, is the leading cause of blindness globally. Müller cells are key players in diabetes-associated retinal inflammation and dysfunction. However, the pathological changes of Müller cells in response to high glucose (HG) and the underlying mechanism remain unclear. The aim of the present study was to investigate the key role of heat shock protein 47 (HSP47) in HG-induced unfolded protein and inflammatory responses. Primary mouse Müller cells were starved in serum-free DMEM overnigh...
Source: Experimental and Therapeutic Medicine - October 22, 2021 Category: General Medicine Authors: Xincheng Sun Chen Chen Hu Liu Shaowen Tang Source Type: research

Gremlin mediates the TGF- β-induced induction of profibrogenic genes in human retinal pigment epithelial cells.
Gremlin mediates the TGF-β-induced induction of profibrogenic genes in human retinal pigment epithelial cells. Exp Ther Med. 2020 Mar;19(3):2353-2359 Authors: Qin D, Jin X, Jiang Y Abstract Proliferative vitreoretinopathy (PVR) is characterised by the contraction and growth of fibrotic membranes on the retina and within the vitreous body. Retinal pigment epithelial (RPE) cells, a major cellular component of the fibrotic membrane, is one of the cell types that have been previously reported to associate with PVR pathogenesis. During PVR, RPE cells undergo increased cell proliferation, migration and the ...
Source: Experimental and Therapeutic Medicine - February 29, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Platelet-derived growth factor-BB promotes proliferation and migration of retinal microvascular pericytes by up-regulating the expression of C-X-C chemokine receptor types 4.
Authors: Xiang DN, Feng YF, Wang J, Zhang X, Shen JJ, Zou R, Yuan YZ Abstract Stromal cell-derived growth factor (SDF)-1α acts as a ligand to C-X-C chemokine receptors 4 (CXCR4) and 7 (CXCR7), which are involved in the formation of choroidal neovascularization. Previous studies have demonstrated crosstalk between the platelet-derived growth factor (PDGF)-BB/PDGF receptor (PDGFR)-β and SDF-1α/CXCR4 axes during tumor neovascularization by increasing the recruitment of pericytes. However, the effects of interactions between these two signaling pathways in retinal microvascular pericytes remain poorly understood. We...
Source: Experimental and Therapeutic Medicine - October 17, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research