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Source: Experimental and Therapeutic Medicine
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Total 206 results found since Jan 2013.
SPTBN2 regulates endometroid ovarian cancer cell proliferation, invasion and migration via ITGB4 ‑mediated focal adhesion and ECM receptor signalling pathway
Exp Ther Med. 2023 Apr 24;25(6):277. doi: 10.3892/etm.2023.11977. eCollection 2023 Jun.ABSTRACTOvarian cancer is as a major contributor to gynaecologic death globally. The present study aimed to investigate the regulatory role of spectrin β non-erythrocytic 2 gene (SPTBN2) in endometroid ovarian cancer and its mechanism of action. According to the Gene Expression Profiling Interactive Analysis (GEPIA) database, SPTBN2 expression is elevated in ovarian cancer tissues and higher SPTBN2 expression indicated a worse prognosis. The present study assessed SPTBN2 mRNA and protein expression levels by reverse transcription-quanti...
Source: Experimental and Therapeutic Medicine - May 19, 2023 Category: General Medicine Authors: La Yang Yuanyuan Gu Source Type: research
Dual specificity phosphatase 22 suppresses mesangial cell hyperproliferation, fibrosis, inflammation and the MAPK signaling pathway in diabetic nephropathy
In conclusion, DUSP22 suppresses HG-induced mesangial cell hyperproliferation, fibrosis, inflammation and the MAPK pathway, implying its potency in DN treatment.PMID:36561966 | PMC:PMC9748649 | DOI:10.3892/etm.2022.11680
Source: Experimental and Therapeutic Medicine - December 23, 2022 Category: General Medicine Authors: Na Ren Shanshan Shi Na Zhao Lingyan Zhang Source Type: research
SIRT3 expression alleviates microglia activation ‑induced dopaminergic neuron injury through the mitochondrial pathway
In conclusion, these results indicated that SIRT3 expression attenuated cell damage caused by microglia activation through the mitochondrial apoptosis pathway in DACs. The mitophagy-NLRP3 inflammasome pathway may also be associated with this neuroprotection. These findings may provide new intervention targets for the survival of dopaminergic neurons and the prevention and treatment of Parkinson's disease.PMID:36168411 | PMC:PMC9475350 | DOI:10.3892/etm.2022.11598
Source: Experimental and Therapeutic Medicine - September 28, 2022 Category: General Medicine Authors: De-Qi Jiang Qing-Min Zang Li-Lin Jiang Cheng-Shu Lu Shi-Hua Zhao Lan-Cheng Xu Source Type: research
GRWD1 affects the proliferation, apoptosis, invasion and migration of triple negative breast cancer through the Notch signaling pathway
In conclusion, GRWD1 knockdown could suppress the proliferation, invasion and migration and promoted apoptosis of TNBC cells through inhibiting the Notch signaling pathway.PMID:35761807 | PMC:PMC9214606 | DOI:10.3892/etm.2022.11400
Source: Experimental and Therapeutic Medicine - June 28, 2022 Category: General Medicine Authors: Liang Yao Fuguo Tian Source Type: research
