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Downregulation of histone-lysine N-methyltransferase EZH2 inhibits cell viability and enhances chemosensitivity in lung cancer cells.
Authors: Cao Z, Wu W, Wei H, Zhang W, Huang Y, Dong Z Abstract Histone-lysine N-methyltransferase EZH2 (EZH2) is the principle component of the polycomb repressive complex 2 (PRC2)/embryonic ectoderm development protein-EZH2 complex, which promotes tumorigenesis by repressing transcription of tumor suppressor genes. EZH2 is considered a key marker in several types of cancer, such as colorectal and prostate cancer. However, the molecular mechanisms and clinical value of EZH2 in lung cancer have not yet been fully investigated. The aim of the present study was to investigate the functions of EZH2 in lung cancer progr...
Source: Oncology Letters - November 27, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Lentivirus-mediated RNA interference targeting EBNA1 gene inhibits the growth of GT-38 cells in vitro and in vivo.
Authors: Wang J, Liang C, Meng F, Xu X, Wu Y, Lu L Abstract Epstein-Barr virus nuclear antigen 1 (EBNA1) is associated with the pathogenesis of Epstein-Barr virus-associated gastric carcinoma (EBVaGC). However, the function of EBNA1 in the growth of EBVaGC cells remains unclear. In the present study, the effects of silencing EBNA1, by RNA interference (RNAi), on the growth of EBVaGC cells were investigated in vitro and in vivo. A lentivirus-mediated RNAi targeting EBNA1 was transfected into the EBVaGC cell line GT-38. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR), western blot analysis, MTT...
Source: Oncology Letters - August 14, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effect of inhibiting Beclin-1 expression on autophagy, proliferation and apoptosis in colorectal cancer.
In conclusion, Beclin-1 played an important role in regulating autophagy, proliferation and apoptosis in HCT116 and SW620 cells. The inhibition of Beclin-1 by RNAi suppressed the autophagic activity and proliferation, but promoted apoptosis in CRC cells. Beclin-1 was the new target of gene therapy for CRC. PMID: 28989537 [PubMed]
Source: Oncology Letters - October 12, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research