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Differential expression of < em > COL4A3 < /em > and collagen in upward and downward progressing types of nasopharyngeal carcinoma
In conclusion, the gene mutation patterns were significantly different between the upward and downward progressing types of NPC. In addition, the expression level of the COL4A3 gene was decreased in the downward progressing type, which might promote NPC metastasis through the downregulation of extracellular collagen expression.PMID:33613712 | PMC:PMC7859474 | DOI:10.3892/ol.2021.12484
Source: Oncology Letters - February 22, 2021 Category: Cancer & Oncology Authors: Xiting Yang Qiuji Wu Fengyang Wu Yahua Zhong Source Type: research

microRNA-144 inhibits cell proliferation and invasion by directly targeting TIGAR in esophageal carcinoma.
Authors: Mu Y, Wang Q, Tan L, Lin L, Zhang B Abstract microRNAs (miRNAs) have been identified to play vital roles in the development and progression of numerous different types of human malignancy, including esophageal squamous cell carcinoma (ESCC). In the present study, the biological function of microRNA-144 (miR-144) was investigated, as well as its underlying molecular mechanism in ESCC. The results revealed that miR-144 expression was significantly decreased, whereas the expression of TP53-inducible glycolysis and apoptosis regulator (TIGAR) was significantly increased in human ESCC tissues when compared with...
Source: Oncology Letters - April 8, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Long non-coding RNA CRNDE regulates cell proliferation, migration, invasion, epithelial-mesenchymal transition and apoptosis in oral squamous cell carcinoma.
In conclusion, silencing CRNDE may inhibit EMT, thus decreasing the migration and invasion of human OSCC cells by repressing the activation of the Wnt/β-catenin signaling pathway, thereby restricting cell growth and promoting cell apoptosis. PMID: 30867767 [PubMed]
Source: Oncology Letters - March 16, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Long non-coding RNA MEG3 inhibits the proliferation and metastasis of oral squamous cell carcinoma by regulating the WNT/ β-catenin signaling pathway.
This study aimed to investigate how long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by regulating WNT/β-catenin signaling pathway in order to explore the antitumor effect of MEG3 and to provide a potential molecular target for the treatment of OSCC. The RT-qPCR technique was used to quantitatively analyze the expression of MEG3 in cancer and adjacent tissues collected from the patients after surgery. Using the Lipofectamine method, the MEG3 overexpression vector and the siRNA interference vector were constructed and transfected into ...
Source: Oncology Letters - September 30, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Targeting of angiopoietin 2-small interfering RNA plasmid/chitosan magnetic nanoparticles in a mouse model of malignant melanoma in vivo.
Authors: Shan XY, Xu TT, Liu ZL, Hu XF, Zhang YD, Guo SZ, Wang B Abstract The aim of the present study was to observe the in vivo targeting characteristic of angiopoietin 2-small interfering RNA (Ang2-siRNA) plasmid/chitosan magnetic nanoparticles in an established nude mouse model of malignant melanoma (MM) under an external magnetic field. The nude mouse MM model was first established, then divided into 3 groups, including the control group, the non-targeting group and the target group, the control group was given normal saline and the non-targeting and targeting groups were administrated particles through the ta...
Source: Oncology Letters - August 9, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Inactivated Wnt signaling in resveratrol-treated epidermal squamous cancer cells and its biological implication.
Authors: Liu ZL, Li H, Liu J, Wu ML, Chen XY, Liu LH, Wang Q Abstract Squamous cell carcinoma (SCC) is the most common epidermal malignancy, and Wnt/β-catenin signaling is frequently activated in SCC. Resveratrol prevents rodent epidermal carcinogenesis, while its effect on human epidermal cancer remains unknown. To address this issue, the impact of resveratrol on the growth and Wnt signaling of skin SCC Colo16 cells were investigated at the cellular and molecular biology levels by flow cytometry, immunocytochemistry, reverse transcription-polymerase chain reaction, western blotting and β-catenin-specific small i...
Source: Oncology Letters - August 9, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Targeted silencing of CXCR4 inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma.
In conclusion, the present study demonstrated that CXCR4 silencing suppressed EMT in OSCC, thus affecting tumor metastasis. PMID: 27602138 [PubMed - as supplied by publisher]
Source: Oncology Letters - September 8, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Construction of Ang2-siRNA chitosan magnetic nanoparticles and the effect on Ang2 gene expression in human malignant melanoma cells.
Authors: Liu ZL, You CL, Wang B, Lin JH, Hu XF, Shan XY, Wang MS, Zheng HB, Zhang YD Abstract The aim of the present study was to construct angiopoietin-2 (Ang2)-small interfering (si)RNA chitosan magnetic nanoparticles and to observe the interference effects of the nanoparticles on the expression of the Ang2 gene in human malignant melanoma cells. Ang2-siRNA chitosan magnetic nanoparticles were constructed and transfected into human malignant melanoma cells in vitro. Red fluorescent protein expression was observed, and the transfection efficiency was analyzed. Reverse transcription-quantitative polymerase chain re...
Source: Oncology Letters - June 19, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression of B cell-specific Moloney murine leukemia virus integration site 1 in vulvar squamous cell carcinoma and its effect on the biological behavior of A-431 cells.
Authors: Bai X, Ouyang L, Li BO, Zhou Y, Wen X Abstract The aim of the present study was to investigate the expression of B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) in vulvar squamous cell carcinoma (VSCC) and vulvar intraepithelial neoplasia (VIN). Furthermore, the present study investigated the effects of BMI-1 expression on the biological behavior of A-431 human epidermoid carcinoma cells. BMI-1 expression in human VSCC and VIN tissues was detected using immunohistochemistry. Subsequently, BMI-1 expression was silenced in A-431 cells using small interfering RNA (siRNA), and BMI-1 ex...
Source: Oncology Letters - January 21, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Synergistic cytotoxicity of cisplatin and Taxol in overcoming Taxol resistance through the inhibition of LDHA in oral squamous cell carcinoma.
This study highlights LDHA as a novel therapeutic target for overcoming Taxol resistance in oral cancer patients using the combined treatments of Taxol and CDDP. PMID: 25789051 [PubMed - as supplied by publisher]
Source: Oncology Letters - June 4, 2015 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research