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Total 10 results found since Jan 2013.

Molecules, Vol. 27, Pages 1990: Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway
In this study, we evaluated the effect of homoplantaginin and its derivative dihydrohomoplantagin on oxLDL-induced endothelial cell injury and atherosclerosis in apoE-/- mice. Our results showedthat both dihydrohomoplantagin and homoplantaginin inhibited apoptosis and the increased level of ICAM-1 and VCAM-1 in oxLDL-stimulated HUVECs and the plaque endothelium of apoE-/- mice. Additionally, both of them restricted atherosclerosis development of apoE-/- mice. Mechanistic studies showed that oxLDL-induced the increase in ROS production, phosphorylation of ERK and nuclear translocation of NF-κB in HUVECs was si...
Source: Molecules - March 19, 2022 Category: Chemistry Authors: Ning Meng Kai Chen Yanhong Wang Jiarong Hou Wenhui Chu Shan Xie Fengying Yang Chunhui Sun Tags: Article Source Type: research

Molecules, Vol. 26, Pages 4919: The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation
In this study, human bladder cancer T24 cells were used as in vitro model for revealing the inhibitory effect and its potential mechanism of SFN on cell growth. Here, a low dose of SFN (2.5 µM) was shown to promote cell proliferation (5.18–11.84%) and migration in T24 cells, whilst high doses of SFN (>10 µM) inhibited cell growth significantly. The induction effect of SFN on nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression at both low (2.5 µM) and high dose (10 µM) was characterized by a bell-shaped curve. Nrf2 and glutathione (GSH) might be the underlying mechanism in the effect of SFN on T24...
Source: Molecules - August 13, 2021 Category: Chemistry Authors: Canxia He Luigina P. Buongiorno Wei Wang Jonathan C. Y. Tang Natalizia Miceli Maria Fernanda Taviano Yujuan Shan Yongping Bao Tags: Article Source Type: research

Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O- β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway
Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O-β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway Molecules doi: 10.3390/molecules26133852 Authors: Xiaohua Wu Jian Xu Yousheng Cai Yuejun Yang Yuancai Liu Shugeng Cao Astragalus membranaceus is a famous herb found among medicinal and food plants in East and Southeastern Asia. The Nrf2-ARE assay-guided separation of an extract from Jing liqueur led to the identification of a nontoxic Nrf2 activator, methylnissolin-3-O-β-D-glucopyranoside (MNG, a component of A. ...
Source: Molecules - June 24, 2021 Category: Chemistry Authors: Xiaohua Wu Jian Xu Yousheng Cai Yuejun Yang Yuancai Liu Shugeng Cao Tags: Article Source Type: research

Molecules, Vol. 25, Pages 1320: Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells
Blough Ahn Evodiamine (EVO) is an indoloquinazoline alkaloid that exerts its various anti-oncogenic actions by blocking phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), mitogen-activated protein kinase (MAPK), c-Met, and nuclear factor kappa B (NF-B) signaling pathways, thus leading to apoptosis of tumor cells. We investigated the ability of EVO to affect hepatocyte growth factor (HGF)-induced c-Met/Src/STAT3 activation cascades in castration-resistant prostate cancer (CRPC). First, we noted that EVO showed cytotoxicity and anti-proliferation activities in PC-3 and DU145 cells. Next, we found that EVO m...
Source: Molecules - March 12, 2020 Category: Chemistry Authors: Hwang Um Chinnathambi Alharbi Narula Namjoshi Blough Ahn Tags: Article Source Type: research

Molecules, Vol. 24, Pages 1377: Regulation of the Nrf2 Pathway by Glycogen Synthase Kinase-3 β in MPP+-Induced Cell Damage
Molecules, Vol. 24, Pages 1377: Regulation of the Nrf2 Pathway by Glycogen Synthase Kinase-3β in MPP+-Induced Cell Damage Molecules doi: 10.3390/molecules24071377 Authors: Armagan Sevgili Gürkan Köse Bilgiç Dagcı Saso Recently, nuclear translocation and stability of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) have gained increasing attention in the prevention of oxidative stress. The present study was aimed to evaluate the regulatory role of glycogen synthase kinase-3β (GSK-3β) inhibition by tideglusib through the Nrf2 pathway in a cellular damage mod...
Source: Molecules - April 7, 2019 Category: Chemistry Authors: Armagan Sevgili G ürkan K öse Bilgi ç Dagc ı Saso Tags: Article Source Type: research

Molecules, Vol. 23, Pages 478: Phycocyanin Protects Against UVB-induced Apoptosis Through the PKC α/βII-Nrf-2/HO-1 Dependent Pathway in Human Primary Skin Cells
ok Chae Phycocyanin (Pc) is one of the active pigment constituents of Spirulina microalgae. It has been used for its potent antioxidant and anti-inflammatory properties. However, the protective effects of Pc against ultraviolet-B (UVB)-induced primary skin cells damage are still undefined. In the present study, we investigated whether Pc prevented UVB-induced apoptotic cell death in human dermal fibroblasts (HDF) and human epidermal keratinocytes (HEK). Pc induced the transcription of heme oxygenase-1 (HO-1). Furthermore, Pc treatments resulted in a marked increase in nuclear factor erythroid-derived 2 (NF-E2)-like 2 (...
Source: Molecules - February 22, 2018 Category: Chemistry Authors: Ki Mo Kim Joo Young Lee A-Rang Im Sungwook Chae Tags: Article Source Type: research

Molecules, Vol. 22, Pages 1754: Emodin Inhibition of Influenza A Virus Replication and Influenza Viral Pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB Pathways
In conclusion, emodin can inhibit IAV replication and influenza viral pneumonia, at least in part, by activating Nrf2 signaling and inhibiting IAV-induced activations of the TLR4, p38/JNK MAPK and NF-κB pathways.
Source: Molecules - October 18, 2017 Category: Chemistry Authors: Jian-Ping Dai Qian-Wen Wang Yun Su Li-Ming Gu Ying Zhao Xiao-Xua Chen Cheng Chen Wei-Zhong Li Ge-Fei Wang Kang-Sheng Li Tags: Article Source Type: research

Molecules, Vol. 22, Pages 969: Docosahexaenoic Acid Induces Expression of Heme Oxygenase-1 and NAD(P)H:quinone Oxidoreductase through Activation of Nrf2 in Human Mammary Epithelial Cells
In conclusion, DHA activates Nrf2, possibly through modification of critical Keap1 cysteine 288 residue and PKCδ-mediated phosphorylation of Nrf2, leading to upregulation of HO-1 and NQO1 expression.
Source: Molecules - June 10, 2017 Category: Chemistry Authors: Hye-Yoon Bang Sin-Aye Park Soma Saeidi Hye-Kyung Na Young-Joon Surh Tags: Article Source Type: research

Molecules, Vol. 21, Pages 1033: Salidroside Suppresses HUVECs Cell Injury Induced by Oxidative Stress through Activating the Nrf2 Signaling Pathway
This study is the first to demonstrate that SAL suppresses HUVECs cell injury induced by oxidative stress through activating the Nrf2 signaling pathway.
Source: Molecules - August 8, 2016 Category: Chemistry Authors: Yao Zhu Ya-Jie Zhang Wei-Wei Liu Ai-Wu Shi Ning Gu Tags: Article Source Type: research

Molecules, Vol. 21, Pages 952: Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). Our previous studies have shown that the total flavonoids (TFs) from Rosa laevigata Michx fruit has various activities, however, there were no papers reporting the role of the TFs against renal IRI. In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. The results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea nitrogen (BUN) levels in rats. Further investigation revealed that the TFs markedly decreas...
Source: Molecules - July 20, 2016 Category: Chemistry Authors: Lisha Zhao Lina Xu Xufeng Tao Xu Han Lianhong Yin Yan Qi Jinyong Peng Tags: Article Source Type: research