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Upregulation of thioredoxin and its reductase attenuates arsenic trioxide ‑induced growth suppression in human pulmonary artery smooth muscle cells by reducing oxidative stress.
In conclusion, upregulation of Trx1 and TrxR1 somewhat decreased cell growth inhibition and death in ATO‑treated HPASMCs, which was accompanied by reduced oxidative stress. PMID: 31789420 [PubMed - as supplied by publisher]
Source: Oncology Reports - December 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Girdin regulates the proliferation and apoptosis of pancreatic cancer cells via the PI3K/Akt signalling pathway.
Authors: Wang S, Lei Y, Cai Z, Ye X, Li L, Luo X, Yu C Abstract Girdin functions as an Akt phosphorylation enhancer (APE), which expedites the proliferation and survival of many types of tumours. However, the influence of Girdin on pancreatic cancer and the underlying molecular mechanisms have yet to be uncovered. Hence, in the present study, we sought to elucidate the function of Girdin in pancreatic cancer malignancy, particularly its role in pancreatic cancer cell proliferation, migration and apoptosis. Immunohistochemistry (IHC) was used to evaluate Girdin expression in pancreatic cancer tissues and to analyse ...
Source: Oncology Reports - June 15, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo.
Authors: Liu J, Dong BF, Wang PS, Ren PY, Xue S, Zhang XΝ, Han Z, Chen G Abstract Doxorubicin (DOX), a broad‑spectrum anthra-cyclin, is in wide clinical use for the treatment and prevention of thyroid cancer. However, the effectiveness of the treatment remains limited due to inherent tumor resistance to DOX. Results of a previous study demonstrated that downregulation of NIN1/RPN12 binding protein 1 homolog (NOB1) expression via adenovirus expression vector carrying NOB1 siRNA (Ad/sh-NOB1) induced cancer apoptosis and increased the radiosensitivity of papillary thyroid carcinoma (PTC) cells. However, whether kn...
Source: Oncology Reports - January 21, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research