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Source: PLoS One
Procedure: Perfusion
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Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice
by Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu
Nutrients are actively taken up by the brain via various transporters at the blood–brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To compensate for decreased brain DHA, orally supplied DHA must be transported from the circulating blood to the brain across the BBB through transport carriers, including major facilitator superfamily domain-containing protein 2a (MFSD2...
Source: PLoS One - February 16, 2023 Category: Biomedical Science Authors: Takuro Iwao Source Type: research
