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Delivery of gene targeting siRNAs to breast cancer cells using a multifunctional peptide complex that promotes both targeted delivery and endosomal release
This study demonstrates the ability of a peptide-based siRNA-delivery system to deliver siRNA into breast cancer cells and cause both protein knockdown and su ppression of the malignant phenotype. Such peptide complexes are likely to become highly useful siRNA-delivery vehicles for the characterization, and potentially for the treatment, of human cancer.
Source: PLoS One - June 30, 2017 Category: Biomedical Science Authors: Jeffrey D. Bjorge Source Type: research

Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer
by Rebecca Graumann, Gabriella A. Di Capua, Juan E. Oyarz ún, Marcos A. Vásquez, Christine Liao, Jorge A. Brañes, Iván Roa, Paola Casanello, Alejandro H. Corvalán, Gareth I. Owen, Iris Delgado, Uwe Zangemeister-Wittke, Annemarie Ziegler Teneurins are a family of highly conserved pair-rule proteins involved in morphogenesis and development of the central nervous system. Their function in adult tissues and in disease is largely unknown. Recent evidence suggests a role for dysregulated expression of Teneurins in human tumors, but sy stematic investigations are missing. Here, we investigated Teneurin-2 and Teneurin-4 exp...
Source: PLoS One - May 4, 2017 Category: Biomedical Science Authors: Rebecca Graumann Source Type: research

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells
by Ming Zhao, Erin W. Howard, Zhiying Guo, Amanda B. Parris, Xiaohe Yang Alcohol consumption is associated with increased breast cancer risk; however, the underlying mechanisms that contribute to mammary tumor initiation and progression are unclear. Alcohol is known to induce oxidative stress and DNA damage; likewise, p53 is a critical modulator of the DNA repair pathw ay and ensures genomic integrity. p53 mutations are frequently detected in breast and other tumors. The impact of alcohol on p53 is recognized, yet the role of p53 in alcohol-induced mammary carcinogenesis remains poorly defined. In our study, we measured a...
Source: PLoS One - April 3, 2017 Category: Biomedical Science Authors: Ming Zhao Source Type: research

Src Inhibition Can Synergize with Gemcitabine and Reverse Resistance in Triple Negative Breast Cancer Cells via the AKT/c-Jun Pathway
ConclusionIn highly gemcitabine-resistant 231 cells, src inhibition can synergize with gemcitabine, reverse drug resistance, inhibit tumor growth/metastasis/stemness of cancer stem cells, possibly via the AKT/c-Jun pathway.
Source: PLoS One - December 29, 2016 Category: Biomedical Science Authors: Zhen-Hua Wu Source Type: research

Caveolin-1 Dependent Endocytosis Enhances the Chemosensitivity of HER-2 Positive Breast Cancer Cells to Trastuzumab Emtansine (T-DM1)
In this study, the relationship between caveolin-1 expression and the chemosensitivity of HER-2-positive breast cancer cells to T-DM1 was investigated. Samples from 32 human breast cancer biopsy and normal tissue specimens were evaluated immunohistochemically for caveolin-1 expression. Caveolin-1 was shown to be expressed in 68% (22/32) of the breast cancer specimens. In addition, eight (72.7%, 8/11) HER-2 positive breast cancer specimens had a higher caveolin-1 expression than normal tissues. HER-2-positive BT-474 and SKBR-3 breast cancer cells that express low and moderate levels of caveolin-1, respectively, were treated...
Source: PLoS One - July 14, 2015 Category: Biomedical Science Authors: Yuan-Chiang Chung et al. Source Type: research

Molecular Modification of Metadherin/MTDH Impacts the Sensitivity of Breast Cancer to Doxorubicin
Conclusion MTDH gene plays a promoting role in the proliferation of breast cancer cells and its high expression may be associated with doxorubicin sensitivity of breast cancer.
Source: PLoS One - May 19, 2015 Category: Biomedical Science Authors: Zhenchuan Song et al. Source Type: research