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Knockdown of PINCH-1 protein sensitizes the Estrogen positive breast cancer cells to chemotherapy induced apoptosis
Conclusion The results suggest that PINCH-1 may be playing an important role in etiopathogenesis of both subtypes breast cancer. However, enhanced apoptosis observed only in estrogen positive and not in estrogen negative cells upon PINCH-1 knockdown point towards participation of some other protein with redundant functions in the later subtype which needs to be investigated.
Source: Pathology Research and Practice - September 30, 2017 Category: Pathology Source Type: research

San Huang Decoction downregulates Aurora kinase A to inhibit breast cancer cell growth and enhance chemosenstivity to anti-tumor drugs
Publication date: Available online 18 May 2016 Source:Pathology - Research and Practice Author(s): Yanlei Xu, Xu Chen, Xiyan Chen, Weihe Bian, Chang Yao, Xiaoqing Zhang, Xiaoshu Zhu, Jiajing Chen, Xiaozhou Ye Our study aimed to explore whether San Huang Decoction (SHD) inhibited the development of breast cancer by regulating Aurora A. Human breast cancer cell lines MCF-7 and MDA-MB-231 were cultured and SHD extract was prepared. Cell growth assay and apoptosis analysis were respectively performed to detect the effects of SHD on breast cancer cells. In addition, the effects of SHD on the expression of Aurora A an...
Source: Pathology Research and Practice - May 17, 2016 Category: Pathology Source Type: research