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Source: Nanomedicine: Nanotechnology, Biology and Medicine
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Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma
Publication date: Available online 11 June 2017 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Forrest M. Kievit, Kui Wang, Tatsuya Ozawa, Aria W. Tarudji, John R. Silber, Eric C. Holland, Richard G. Ellenbogen, Miqin Zhang Glioblastoma (GBM) remains incurable, and recurrent tumors that rarely respond to standard-of-care radiation and chemo therapies. Therefore, strategies that enhance the effects of these therapies should provide significant benefits to GBM patients. We have developed a nanoparticle delivery vehicle that can stably bind and protect nucleic acids for specific delivery into brain tumo...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 11, 2017 Category: Nanotechnology Source Type: research