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Source: Nanomedicine: Nanotechnology, Biology and Medicine
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Total 65 results found since Jan 2013.
Tyrosine-modified linear PEIs for highly efficacious and biocompatible siRNA delivery in vitro and in vivo
Publication date: Available online 29 April 2021Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Michael Karimov, Marion Schulz, Tim Kahl, Sandra Noske, Malgorzata Kubczak, Ines Gockel, René Thieme, Thomas Büch, Anja Reinert, Maksim Ionov, Maria Bryszewska, Heike Franke, Ute Krügel, Alexander Ewe, Achim Aigner
Source: Nanomedicine: Nanotechnology, Biology and Medicine - April 29, 2021 Category: Nanotechnology Source Type: research
Simultaneous inhibition of CD73 and IL-6 molecules by siRNA-loaded nanoparticles prevents the growth and spread of Cancer
Publication date: Available online 24 March 2021Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Sima Emadi Allahyari, Farnaz Hajizadeh, Angelina Olegovna Zekiy, Niloofar Mansouri, Parisa Sahami Gilan, Seyedeh Mahboubeh Mousavi, Ali Masjedi, Hadi Hassannia, Majid Ahmadi, Hamed Mohammadi, Mehdi Yousefi, Sepideh Izadi, Naime Majidi Zolbanin, Reza Jafari, Farhad Jadidi-Niaragh
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 25, 2021 Category: Nanotechnology Source Type: research
Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth
Publication date: Available online 3 March 2021Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Hendrik Setia Budi, Sepideh Izadi, Anton Timoshin, Sima Heydarzadeh Asl, Behzad Beyzai, Amir Ghaderpour, Fatemeh Alian, Farzaneh Sadat Eshaghi, Seyedeh Mahboubeh Mousavi, Behnam Rafiee, Afshin Nikkhoo, Armin Ahmadi, Hadi Hassannia, Majid Ahmadi, Mozhdeh Sojoodi, Farhad Jadidi-Niaragh
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 3, 2021 Category: Nanotechnology Source Type: research
Local delivery of RhoA siRNA by PgP nanocarrier reduces inflammatory response and improves neuronal cell survival in a rat TBI model
Publication date: Available online 28 November 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Christian Macks, DaUn Jeong, Jeoung Soo Lee
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 29, 2020 Category: Nanotechnology Source Type: research
Growth inhibitory and anti-metastatic activity of epithelial cell adhesion molecule targeted three-way junctional Delta-5-Desaturase siRNA nanoparticle for breast cancer therapy
Publication date: Available online 12 September 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Harshit Shah, Lizhi Pang, Hongzhi Wang, Dan Shu, Steven Y. Qian, Venkatachalem Sathish
Source: Nanomedicine: Nanotechnology, Biology and Medicine - September 14, 2020 Category: Nanotechnology Source Type: research
siRNA based drug design, quality, delivery and clinical translation
Publication date: Available online 13 June 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Md Abdus Subhan, VP Torchilin
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 15, 2020 Category: Nanotechnology Source Type: research
siRNA and chemotherapeutic molecules entrapped into a redox-responsive platform for targeted synergistic combination therapy of glioma
Publication date: Available online 13 May 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Lijuan Wen, Changlong Wen, Fengtian Zhang, Kai Wang, Hong Yuan, Fuqiang Hu
Source: Nanomedicine: Nanotechnology, Biology and Medicine - May 14, 2020 Category: Nanotechnology Source Type: research
Trimethyl chitosan-hyaluronic acid nano-polyplexes for intravitreal VEGFR-2 siRNA delivery: Formulation and in-vivo efficacy evaluation
Publication date: Available online 10 March 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Farkhondeh Chaharband, Narsis Daftarian, Mozhgan Rezaei Kanavi, Reyhaneh Varshochian, Maliheh Hajiramezanali, Parisa Norouzi, Ehsan Arefian, Fatemeh Atyabi, Rassoul Dinarvand
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 11, 2020 Category: Nanotechnology Source Type: research
Folate receptor-targeted RNAi nanoparticles for silencing STAT3 in tumor-associated macrophages and tumor cells
Publication date: Available online 18 February 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Jing Chen, Yushun Dou, Yue Tang, Xinru ZhangAbstractWe developed a STAT3 silencing siRNA to both tumor cells and M2 macrophages. The dual-targeting system prepared by electronic self-assembly was composed of folic acid-conjugated carboxymethyl chitosan for targeting and cationic chitosan derivatives for siRNA package. The effects of siRNA delivery was investigated in M2 macropahges and Lewis lung cancer cells(LLC). Due to the enhanced delivery efficiency, the dual-targeting delivery system exhibited a hig...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 19, 2020 Category: Nanotechnology Source Type: research
Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration
Publication date: Available online 27 October 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Vasyl Sava, Oksana Fihurka, Anastasia Khvorova, Juan Sanchez-RamosAbstractTherapies to lower gene expression in brain disease currently require chronic administration into the cerebrospinal fluid (CSF) by intrathecal infusions or direct intracerebral injections. Though well-tolerated in the short-term, this approach is not tenable for a life-time of administration. Nose-to-brain delivery of enriched chitosan-based nanoparticles loaded with anti-HTT siRNA was studied in a transgenic YAC128 mouse model of Hu...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 28, 2019 Category: Nanotechnology Source Type: research
Site-specific intestinal DMT1 silencing to mitigate iron absorption using pH-sensitive multi-compartmental nanoparticulate oral delivery system
We report a novel pH-sensitive multi-compartmental nanoparticulate (MCP) oral delivery system that encapsulates siRNA for silencing the divalent metal transporter 1 (DMT1) gene, a primary iron transporter highly expressed in the intestine. The gelatin nanoparticles-coated with Eudragit® L100–55 are able to protect siRNA from intracellular degradation and allow for sustained release of siRNA in the cytosol. When orally-administered, Eudragit® L100–55 based MCPs containing DMT1 siRNA/gelatin NPs specifically and significantly decreased the expression of DMT1 mRNA in the duodenum, which consequently decreased intestinal...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 16, 2019 Category: Nanotechnology Source Type: research
Single-Cell Kinetics of siRNA-Mediated mRNA Degradation
Publication date: Available online 8 August 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Rafał Krzysztoń, Daniel Woschée, Anita Reiser, Gerlinde Schwake, Helmut H. Strey, Joachim O. RädlerAbstractRNA interference (RNAi) enables the therapeutic use of small interfering RNAs (siRNAs) to silence disease-related genes. The efficiency of silencing is commonly assessed by measuring expression levels of the target protein at a given time point post-transfection. Here, we determine the siRNA-induced fold change in mRNA degradation kinetics from single-cell fluorescence time-courses obtained using li...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - August 8, 2019 Category: Nanotechnology Source Type: research
Delivery of siRNA using folate receptor-targeted pH-sensitive polymeric nanoparticles for rheumatoid arthritis therapy
Publication date: Available online 22 May 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Xiangshi Sun, Shiyan Dong, Xiangyu Li, Kongtong Yu, Fengying Sun, Robert J. Lee, Youxin Li, Lesheng TengAbstractSystemic delivery of siRNA to target tissues is difficult to achieve owing to its limited cellular uptake and poor serum stability. Herein, polymeric nanoparticles were developed for systemic administration of siRNA to inflamed tissues. The polymeric nanoparticles were composed of PK3 as a pH-sensitive polymer, folate-polyethyleneglycol-poly(lactide-co-glycolide) as a targeting ligand, and a DOTAP/si...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - May 23, 2019 Category: Nanotechnology Source Type: research
Silencing AXL by covalent siRNA-gelatin-antibody nanoconjugate inactivates mTOR/EMT pathway and stimulates p53 for TKI sensitization in NSCLC
Publication date: Available online 12 May 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Dhananjay Suresh, Ajit Zambre, Soumavo Mukherjee, Shreya Ghoshdastidar, Yuexu Jiang, Trupti Joshi, Anandhi Upendran, Raghuraman KannanAbstractNon-small cell lung cancer (NSCLC) is the leading cause of cancer mortality with the 5-year survival rate remains a dismal 16% for the past 40 years. Drug resistance is a major obstacle to achieving long-term patient survival. Identifying and validating molecular biomarkers responsible for resistance and thereby adopting multi-directional therapy is necessary to imp...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - May 12, 2019 Category: Nanotechnology Source Type: research
Sirtuin 6 mediated stem cell Cardiomyogenesis on protein coated Nanofibrous scaffolds
This study, thus, demonstrates that protein coated scaffolds can augment cardiomyogenic differentiation of stem cells through a combination of topographical and biomolecular signals.Graphical AbstractCollagen coated polymer nanofibers promote stem cell cardiomyogenesis through Sirtuin6-mediated Wnt signaling pathway.
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 27, 2019 Category: Nanotechnology Source Type: research
