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Rational modification of oligoarginine for highly efficient siRNA delivery: structure–activity relationship and mechanism of intracellular trafficking of siRNA
This study present a novel cell penetrating peptide-based siRNA delivery system utilizing modified oligo-arginine demonstrating a successful siRNA delivery approach. Graphical abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - February 13, 2015 Category: Nanotechnology Source Type: research

Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum
In this study the receptor specific uptake of folic acid-functionalized iron oxide nanoparticles was determined in ovarian cancer cells. It was found that the presence of serum proteins is an absolute requirement for the uptake of these nanoparticles. The described strategy for receptor-mediated uptake of nanoparticles with pre-defined surface chemistry may enable a better targeting of nanoparticles for additional therapeutic and imaging applications. Graphical abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 10, 2014 Category: Nanotechnology Source Type: research

Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system
This study demonstrates superior therapeutic properties of siRNA when combined with a dendrimer-based targeted nano-delivery system. Similar approaches may eventually gain clinical utility following additional studies determining safety and efficacy. Graphical abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 10, 2014 Category: Nanotechnology Source Type: research

Atg5 deficit exaggerates the lysosome formation and cathepsin B activation in mice brain after lipid nanoparticles injection
Publication date: November 2014 Source:Nanomedicine: Nanotechnology, Biology and Medicine, Volume 10, Issue 8 Author(s): Nan-nan Lu , Jun Liu , Yun Tian , Mei-hua Liao , Huan Wang , Ying-mei Lu , Rong-rong Tao , Ling-juan Hong , Shuang-shuang Liu , Kohji Fukunaga , Yong-zhong Du , Feng Han The present study was designed to investigate the role of autophagy-lysosome signaling in the brain after application of nanoparticles. Here, lipid nanoparticles (LNs) induced elevations of Atg5, P62, LC3 and cathepsin B in mice brain. The transmission electron microscopy revealed a dramatic elevation of lysosome vacuoles colocalized w...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 10, 2014 Category: Nanotechnology Source Type: research

A nano-enabled cancer-specific ITCH RNAi chemotherapy booster for pancreatic cancer
Publication date: Available online 6 October 2014 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Maria de la Fuente , Marie-Christine Jones , Manuel J. Santander-Ortega , Anja Mirenska , Preethi Marimuthu , Ijeoma Uchegbu , Andreas Schätzlein Gemcitabine is currently the standard therapy for pancreatic cancer. However, growing concerns over gemcitabine resistance mean that new combinatory therapies are required to prevent loss of efficacy with prolonged treatment. Here, we suggest that this could be achieved through co-administration of RNA interference agents targeting the ubiquitin ligase ITCH. S...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 4, 2014 Category: Nanotechnology Source Type: research

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