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Source: GEO: Gene Expression Omnibus
Cancer: Prostate Cancer
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Total 36 results found since Jan 2013.
GSE242255 DNA-PKcs is a key transcriptional and splicing regulator of AR-Vs in advanced prostate cancer
Contributors : Luke Gaughan ; Beth Adamson ; Nicholas BrittainSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the role of DNA-PKcs and RBMX in the regulation of androgen receptor variants we used the CWR22Rv1-AR-EK and CWR22Rv1 cell line in which DNA-PKcs or RBMX has been knocked down by siRNA or DNA-PKcs was inhibited with 1 µM NU7441, NU5455 or AZD7648. We then performed gene expression analysis using data obtained from RNA-seq at two time points (72 hours knockdown and 24 hours drug treatment).
Source: GEO: Gene Expression Omnibus - September 11, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE217342 TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination
Contributors : Qianghua Zhou ; Tianxin Lin ; Hai HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe demonstrated that TSPAN18 was overexpressed in prostate cancer (PCa) and markedly accelerated PCa cell migration and invasion in vitro and bone metastasis in vivo by inhibiting E3 ligase tripartite motif containing 32 (TRIM32)-mediated stromal interaction molecule ubiquitination and degradation. To further investigate the genes regulated by TSPAN18, we knockdown TSPAN18 by siRNA and performed high-throughput sequence. So we identify a series of genes regulated by TSPAN18.
Source: GEO: Gene Expression Omnibus - January 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE169129 VPRBP, a novel androgen receptor and OGT target is an essential mediator of cellular transformation in prostate cancer
In this study, we employed chromatin immunoprecipitation coupled with massive parallel sequencing (ChIP-seq) to identify changes in p53 binding to the genome in VPRBP knockdown LNCaPs compared to scrambled siRNA transfected control cells. Stabilization of p53 was associated increased p53 recruitment to the chromatin.
Source: GEO: Gene Expression Omnibus - September 22, 2022 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE194248 Human prostate cancer cells (VCaP and AIVCaP): siAR alone (single siRNA) vs. siAR plus OPRK1 (combo-siRNA)
Contributors : Yuki Makino ; Takashi KobayashiSeries Type : Expression profiling by arrayOrganism : Homo sapiensThrough comparative genomics using PDX models of androgen-dependent (AD) and castration-resistant (CR) tumors, we identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant growth of prostate cancer cells in culture and in vivo, suggesting OPRK1 as a therapeutic target.To gain insight with regard to biological function of OPRK1 under androgen-depleted condition, we set up two distinct comparisons us...
Source: GEO: Gene Expression Omnibus - April 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE199026 ATF6 is required for the survival of castration-resistant prostate cancer cells
Contributors : Tingting Zhang ; Faming Zhao ; Xia ShengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo gain insight into the global ATF6 target gene profile in prostate cancer cells, we performed RNA-seq analysis in DU145 cells upon either ATF6 siRNA-mediated knockdown (siATF6) or Ceapin-A7-mediated ATF6 α inhibition.
Source: GEO: Gene Expression Omnibus - March 23, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE172094 siRNA-mediated E2F1 and E2F2 silencing in growth-stimulated prostate cancer cells
Contributors : Salma Ben-Salem ; Eduardo Cortes ; Qiang Hu ; Song Liu ; Hannelore HeemersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the effect of siRNA-mediated E2F1 and E2F2 silencing in growth-stimulated prostate cancer cells.
Source: GEO: Gene Expression Omnibus - October 14, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE159839 siRNA mediated HDAC1 knockdown in the LNCaP prostate cancer cell line
Contributors : Simone Bauer ; Holger S ültmannSeries Type : Expression profiling by arrayOrganism : Homo sapienssiRNA mediated HDAC1 knockdown in the LNCaP prostate cancer cell line.
Source: GEO: Gene Expression Omnibus - March 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE114052 AR regulated transcriptome in prostate cancer cells
Contributors : Dingxiao Zhang ; Qiang Hu ; Dean G TangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIt has been well established that the transcription factor androgen receptor (AR) is obligatory for prostate cancer (PCa) development and progression, but the precise role of the AR in these processes is still unclear. To dissect the role of AR in shaping the transcriptome of prostate cancer cells, RNA-seq data were obtained from AR-positive LNCaP cells treated with various regimens to manipulate endogenous AR signaling. LNCaP cells were cultured in normal medium containing fetal bovi...
Source: GEO: Gene Expression Omnibus - March 4, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE139962 Impact of splicing factors (ESRP1 and KHDRBS3) on prostate cancer biology
Contributors : Dingxiao Zhang ; Qiang Hu ; Dean G TangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysregulation of mRNA alternative splicing (AS) has been implicated in development and progression of hematological malignancies. How the global AS dysregulation contributes to the development and progression of solid tumors remains generally unclear. Recently, we show that many splicing factors (such as ESRP1 and KHDRBS3) are overexpressed in human primary prostate cancer (PCa) versus normal tissues. To further determine the biological impact of splicing factors on PCa aggressiveness...
Source: GEO: Gene Expression Omnibus - March 4, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE125826 Regulation of the Integrated Stress Response through ATF4 and FAM129A in Prostate Cancer
Contributors : Nora P ällmann ; Marte Livgårda ; Martina Tesikova ; Hatice Z Nenseth ; Yixin Jin ; Dogukan Koc ; Nermin Kahraman ; Hamada M Mokhlis ; Bulent Ozpolat ; Ladan Fazli ; Paul S Rennie ; Yang Jin ; Fahri SaatciogluSeries Type : Expression profiling by arrayOrganism : Homo sapiensCancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the integrated stress response (ISR) that is important in normal physiology as well as disease states, including cancer. Since ISR can serve as a lever between survival and death, regulated contr...
Source: GEO: Gene Expression Omnibus - November 1, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE123970 Role for citron kinase in prostate cancer growth
Contributors : Salma Ben-Salem ; Eduardo Cortes ; Qiang Hu ; Song Liu ; Hannelore HeemersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the effect of siRNA-mediated CIT silencing on androgen-responsive genes in LNCaP cells.
Source: GEO: Gene Expression Omnibus - October 1, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE117535 KMT9a writes the H4K12me1 histone mark and controls metabolism and proliferation of castration-resistant prostate cancer cells RNA-seq
Contributors : Roland Sch üle ; Dominica Willmann ; Eric MetzgerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe aim of the RNA-seq was to identify the KMT9 transcriptome in PC-3M cells. The MCF10A breast epithelial cells that do not express KMT9a were used to show that the siRNA against KMT9 show no off-target effects.
Source: GEO: Gene Expression Omnibus - June 26, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE106774 Risk SNPs mediated promoter-enhancer switching promotes prostate cancer progression through lncRNA PCAT19 (RNA-seq data sets)
Contributors : Junjie Hua ; Housheng H HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo determine the functional mechanisms of PCAT19-long isoform and HNRNPAB, we conducted siRNA knockdown RNA-sequencing in prostate cancer cell line V16A.
Source: GEO: Gene Expression Omnibus - March 11, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE116728 Contribution of SRF and Nkx2-5 to androgen-dependent gene expression in prostate cancer
Contributors : Salma Ben-Salem ; Dhirodatta Senapati ; Varadha Balaji Venkadakrishnan ; Yixue Su ; Eduardo Cortes ; Qiang Hu ; Song Liu ; Hannelore HeemersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study and compare the effect of siRNA-mediated SRF or Nkx2-5 silencing on androgen-responsive genes in LNCaP cells.
Source: GEO: Gene Expression Omnibus - January 15, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE103864 Identification of global XBP1s target gene expression in human prostate cancer cells
Contributors : Xia Sheng ; Fahri Saatcioglu ; Lukas SimonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo gain insight into the global XBP1s target gene profile in prostate cancer cells, we performed RNA-seq analysis in LNCaP cells upon either XBP1 siRNA-mediated knockdown (siXBP1) or MKC8866-mediated IRE1 α inhibition.
Source: GEO: Gene Expression Omnibus - October 30, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
