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GSE234780 Knockdown TIMM13 in A549 lung cancer cell line
Contributors : Zhaozhao Zhao ; Ting NiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe depleted TIMM13 using short interfering RNA (siRNA) in A549 lung cancer cells, and found that silencing of TIMM13 could significantly inhibit A549 cell proliferation. Thus, we conducted RNA-seq in the A549 cells transduced with either nontargeting siRNA or two distinct TIMM13-specific siRNAs. We observed widespread gene expression change in A549 cells upon TIMM13 knockdown.
Source: GEO: Gene Expression Omnibus - June 17, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE222598 Effect of SF3B4 depletion on gene expression of A549 lung cancer cell
Contributor : Tao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function SF3B4 during the progression of lung cancer, A549 cells with either SF3B4 siRNA or scramble siRNA were used for RNA-seq.
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE161226 HEDGEHOG/GLI Modulates The PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas
Contributors : Yiyun Sun ; Ying ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe previously demonstrated that proline-rich protein 11 (PRR11) and spindle and kinetochore associated 2 (SKA2) constituted a head-to-head gene pair driven by a prototypical bidirectional promoter, and this gene pair synergistically promoted the development of non-small-cell lung cancer. However, the signaling pathways leading to the ectopic expression of this gene pair remain obscure. In the present study, we first analyzed the lung squamous cell carcinoma (LSCC) relevant RNA sequencing data from the...
Source: GEO: Gene Expression Omnibus - November 10, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE196499 Gene expression (GeneChip) data from scramble- and CRMP2A siRNA-treated A549 cells.
Contributors : Aristeidis E Boukouris ; Evangelos D MichelakisSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe sought to assess how temporary loss of the microtubule-associated protein CRMP2A could affect global gene expression in the A549 lung cancer cells.We used microarrays to identify differentially regulated genes when CRMP2A is temporarily removed from A549 cells using siRNA.
Source: GEO: Gene Expression Omnibus - May 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE112429 HMGB1 and Alu-siRNA inhibit the growth of human lung tumor cells
Contributors : Warayupa Thompat ; Apiwat MutiranguraSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe performed expression profiling using microarray technology. The expression profiling identified genes or mechanism potentially regulating the proliferation of human lung cancer cells by BoxA of HMGB1 and Alu-siRNA transfection. The RNAs of our experiment were hybridized with Agilent SurePrint G3 Human GE 8X60K, V3 Microarrays (Agilent ®).
Source: GEO: Gene Expression Omnibus - March 26, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE111130 Genes regulated by TAZ or YAP in A549 cell
Contributors : Hideaki Isago ; Akihisa Mitani ; Yu Mikami ; Masafumi Horie ; Hirokazu Urushiyama ; Yasuhiro Terasaki ; Takahide NagaseSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo investigate the roles of TAZ and YAP in lung cancer cell proliferation, we compared the expression profiles of A549transfected with control siRNA, siTAZ, and siYAP.
Source: GEO: Gene Expression Omnibus - February 29, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE139319 Differentially expressed genes after siRNA transfection in human cancer cell lines (SBC and T24)
Contributors : Naohiko Seki ; Yasutaka YamadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (miRNA) in human cancer, several cell lines (lung cancer and bladder cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - October 25, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE119512 Effects of Bloom RNAi on Transcriptomes in A549 Cells
Contributors : Bin Shan ; Simon AlsagerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe profiled transcriptomes in human lung cancer cell line A549 when the expression of Bloom was knockdown by the siRNA specific to Bloom.
Source: GEO: Gene Expression Omnibus - September 6, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE119510 Effects of HOTAIR RNAi on Transcriptomes in H23 Cells
Contributors : Bin Shan ; Simon AlsagerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe profiled transcriptomes in human lung cancer cell line H23 when the expression of HOTAIR was knockdown by the siRNA specific to an HOTAIR isoform HOTAIR-N (NR_047517).
Source: GEO: Gene Expression Omnibus - September 6, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115909 Differentially expressed genes after siRNA transfection in human cancer cell lines
Contributors : Naohiko Seki ; Yasutaka YamadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (siRNAs) in human cancer, several cell lines (lung cancer, breast cancer and pancreatic cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - June 18, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE113066 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (SK-MES, MDA-MB-231, MKN and 786-O)
Contributors : Naohiko Seki ; Yasutaka YamadaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (lung cancer, breast cancer, gastric cancer and renal cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - April 13, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE66606 Gene expression profiling of Calu-6 lung cancer cells transfected with scrambled siRNA and LAPTM4B-specific siRNA
Contributors : Yuho Maki ; Humam KadaraSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe recently characterized the adjacent airway field of cancerization in NSCLC by whole transcriptome expression analysis and demonstrated that lysosomal protein transmembrane 4 beta (LAPTM4B) was an elevated field cancerization marker in NSCLCs and in adjacent but not in distant normal-appearing airways.We also found that LAPTM4B was up-regulated in NSCLCs compared to normal lung and promoted anchorage-dependent growth of lung cancer cells. Previous reports suggested that LAPTM4B is activated following metabolic and gen...
Source: GEO: Gene Expression Omnibus - August 1, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE81727 Cordycepin induces apoptosis by caveolin-1 mediated JNK’s regulation of Foxo3a in lung cancer A549 cells
Contributors : Jung M Kim ; Ik-Soon JangSeries Type : Expression profiling by arrayOrganism : Homo sapiensc-Jun N-terminal kinase (JNK) plays a pivotal role in the regulation of cancer cell apoptosis. Previous studies have revealed that forkhead transcription factor (Foxo3a) is a critical effector of JNK-mediated tumor suppression. However, it is not clear whether caveolin-1 (CAV1) mediated JNK/Foxo3a pathway is involved in cancer cell apoptosis. We found that cordycepin upregulates CAV1 expression, which was accompanied by JNK phosphorylation (p-JNK), which induced Foxo3a translocation into the nucleus, resulting in the u...
Source: GEO: Gene Expression Omnibus - May 24, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE79228 Gene expression profiling of NCI-H292 cells after treatment of TFAP2C-specific siRNA
Contributors : JiHoon Kang ; Wanyeon Kim ; Sungmin Lee ; OhJin Kwon ; Jahyun Chun ; Beomseok Son ; EunGi Kim ; Jae-Myung Lee ; HyeSook Youn ; BuHyun YounSeries Type : Expression profiling by arrayOrganism : Homo sapiensNon-small cell lung cancer (NSCLC) remains one of the leading causes of death worldwide, and thus, new molecular targets need to be identified to improve treatment efficacy. Enhanced TFAP2C expression was found in lung cancer patient tissues and lung cancer cell lines, and its overexpression promoted cell proliferation and cell cycle progression.We conducted microarrays to find the possible downstream effect...
Source: GEO: Gene Expression Omnibus - March 16, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE66604 Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET inhibitor in Non-Small Cell Lung Cancer
In this study, we tried to identify the mechanism of acquired resistance to MET inhibitor. We analyzed the antitumor effects of two MET inhibitors, PHA-665752 and crizotinib, in 10 NSCLC cell lines. EBC1 cells with MET amplification were the only cells that were sensitive to both MET inhibitors. We established PHA-665752-resistant EBC1 cells, namely EBC1-R cells. EBC1-R cells showed overexpression of ATP-binding cassette sub-family B member 1 (ABCB1) as well as phosphorylation of MET. EBC1-R cells grew as cell spheres that exhibited cancer stem cell-like (CSC) properties and epithelial mesenchymal transition (EMT). The lev...
Source: GEO: Gene Expression Omnibus - March 7, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research