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Abstract P098: G-protein Coupled Estrogen Receptor Stimulates Capillary Formation by Human Umbilical Vein Endothelial Cells via ALK1-SMAD 1/5/8 Pathway Activation Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Estradiol (E2) induces vascular repair by promoting endothelial growth and capillary formation. Based on our previous findings that the capillary stimulating effects of E2 are mimicked by its non-permeable analog, BSA-tagged E2, we hypothesize that the stimulatory effects are potentially mediated via the newly discovered membrane bound G-protein coupled estrogen receptor (GPER). To investigate this, we assessed capillary formation by endothelial cells in response to E2, and GPER agonist (G1)and antagonist (G15) in a 2-D matrigel based assay. Capillary formation was assessed microscopically by quantifying junction/sprout fo...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Unterleutner, E., Rigassi, L., Barchiesi, F., Imthurn, B., Dubey, R. K. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research