Filtered By:
Source: Hypertension
This page shows you your search results in order of relevance. This is page number 2.
Order by Relevance | Date
Total 48 results found since Jan 2013.
Abstract P087: PDI via Keap1/Nrf2 Pathway Regulates Renal AT1 Receptors and Blood Pressure in Aging Rats Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Renal angiotensin AT1 receptor (AT1R) plays pivotal role in the regulation of blood pressure (BP). We recently reported that age-associated oxidative stress causes hyper-activation of AT1R and hypertension in the aging Fischer Brown Norway (FBN) rats. Our objective was to understand the mechanism of higher oxidative stress contributing to the impaired AT1R function in the aged FBNs. Nrf2 transcription factor protects kidney from oxidative stress by activating the transcription of diverse antioxidant and detoxifying enzymes. Kelch-like ECH-associated protein 1 (keap1) inhibit Nrf2 activity by sequestering Nrf2 in cytosol. W...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Wang, X., Asghar, M. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research
Abstract 122: Activation of Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) Enhances Cyclooxygenase 2 Expression via Promoter Antioxidant Response Element in Preglomerular Vascular Smooth Muscle Cells (PGVSMCs) Session Title: Concurrent XVIII C: Oxidative Stress II
In conclusion, these results show a novel role of Nrf2 in inducing COX2 expression through binding to promoter ARE in the absence of increased ROS in rat PGVSMCs.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Luo, Z., Welch, W. J., Wilcox, C. S. Tags: Session Title: Concurrent XVIII C: Oxidative Stress II Source Type: research
Abstract 277: Elevated C-Reactive Protein Contributes to Preeclampsia via Kinin Signaling Pathways Poster Session I
Preeclampsia (PE) is a serious pregnancy disease characterized by hypertension and proteinuria. Despite intensive research efforts, the underlying cause of PE remains a mystery. PE is, however, associated with abnormalities of the immune system. Here we report that the levels of C-reactive protein (CRP), an important acute phase reactant, were significantly elevated in the plasma of human with PE at the third trimester. Next, we found that CRP protein levels in the placentas of PE patients were also significantly increased compared to controls. In an effort to determine the exact role of elevated CRP in PE, we infused CRP ...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Parchim, N., Wang, W., Iriyama, T., Liu, C., Siddiqui, A. H., Blackwell, S., Sibai, B., Kellems, R. E., Xia, Y. Tags: Poster Session I Source Type: research
Abstract 601: Bcl10 Deficiency of Both Cardiac Cells and Bone Marrow Derived Cells Attenuates Angiotensin (Ang) II-induced Target Organ Damage Poster Session II
Conclusion Our results demonstrate that cardiac fibrosis in Bcl10 KO mice depends on both immune/BM-derived cells and resident cardiac cells.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Marko, L., Henke, N., Park, J.-K., Spallek, B., Qadri, F., Apel, I. J., Oravecz-Wilson, K., Przybyl, L., Luft, F. C., Dechend, R., Ruland, J., Lucas, P. C., McAllister-Lucas, L. M., Mueller, D. N. Tags: Poster Session II Source Type: research
Hypoxia-Independent Upregulation of Placental Hypoxia Inducible Factor-1{alpha} Gene Expression Contributes to the Pathogenesis of Preeclampsia Preeclampsia
Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and beneficial response to hypoxia, whereas chronically elevated HIF-1α is associated with multiple disease conditions, including preeclampsia, a serious hypertensive disease of pregnancy. However, the molecular basis underlying the persistent elevation of placental HIF-1α in preeclampsia and its role in the pathogenesis of preeclampsia are poorly understood. Here we report that Hif-1α mRNA and HIF-1α protein were elevated in the placentas of pregnant mice infused with angiotensin II type I receptor agonistic autoa...
Source: Hypertension - May 13, 2015 Category: Cardiology Authors: Iriyama, T., Wang, W., Parchim, N. F., Song, A., Blackwell, S. C., Sibai, B. M., Kellems, R. E., Xia, Y. Tags: Other hypertension Preeclampsia Source Type: research
Abstract 100: Sorting Nexin 1: Molecular Mechanisms and Pharmacogenomics Session Title: Concurrent XVI A: Oxidative Stress I
Sorting nexin 1 (SNX1) plays a pivotal role for the normal activity of renal dopamine D5 receptor (D5R). Kidney-restricted, Snx1-siRNA depletion of SNX1 results in impaired natriuretic response to salt load and hypertension in mice. Genetic ablation of the Snx1 gene (Snx1-/-) resulted in increased oxidative stress, impaired sodium excretion, and elevated systolic blood pressure (SBP, 131.3±6.4 mm Hg, n=5) in mice. The D5R has antioxidant properties by negatively regulating the expression of the NADPH oxidase (NOX). We found that NOX1, NOX2, and p47phox, as well as the antioxidant PON2, conceivably as compensation, w...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Yang, J., Asico, L., Beitelshees, A., Wang, X., Jones, J., Armando, I., Cuevas, S., Zeng, C., Felder, R., Weinman, E., Jose, P., Villar, V. A. M. Tags: Session Title: Concurrent XVI A: Oxidative Stress I Source Type: research
Abstract P180: Dopamine D2 Receptors Regulate Wnt Signaling and Apoptosis in Human Renal Proximal Tubule Cells Session Title: Genetics, Epigenetics, Proteomics and Metabolomics
Previous work from our laboratory indicates that the dopamine D2 receptor (D2R) in the kidney has a direct role in regulating renal inflammation and injury and blood pressure. Some common single nucleotide polymorphisms (D2R SNPs; rs 6276, 6277, and 1800497) in the human DRD2 gene are associated with decreased D2R expression and function. Immortalized renal proximal tubule cells (RPTCs) from subjects carrying D2R SNPs (RPTC-D2R SNPs) express less D2Rs than RPTCs carrying no D2R SNPs (RPTC-D2R WT) (62±4 vs 100±6%; P<0.04) and a pro-inflammatory and pro-fibrotic phenotype with markers of epithelial mesenchym...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Han, F., Zhang, Y., Konkalmatt, P., Jones, J. E., Gildea, J., Felder, R. A., Jose, P. A., Armando, I. Tags: Session Title: Genetics, Epigenetics, Proteomics and Metabolomics Source Type: research
Abstract P239: (Pro)Renin Receptor Contributes to Albumin Overload Nephropathy: Role of Site-1 Protease-Derived Soluble (Pro) Renin Receptor Session Title: Onsite Poster Competition I With Reception
(Pro) renin receptor (PRR) is a new member of the renin-angiotensin system (RAS) and its role in chronic kidney disease largely remains elusive. We tested the role of PRR in albumin overload (OA) nephropathy. Uninephretomized Sprague-Dawley rats were treated for 7 weeks with vehicle, bovine serum albumin (BSA) (5 g/kg/d via a single i.p. injection) or in combination with PRO20 (500 μg/kg/d via i.p. 3 times a day). The OA rat exhibited severe proteinuria (23-fold), interstitial fibrosis, and oxidative stress, accompanied with increases in urinary renin activity (3.6-fold), urinary angiotensinogen (AGT, 3.6-fold), urinary A...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hui Fang, Chuanming Xu, Aihua Lu, Chang-Jiang Zou, Shiying Xie, Yanting Chen, Li Zhou, Mi Liu, Lei Wang, Weidong Wang, Tianxin Yang Tags: Poster Abstract Presentations Source Type: research
Abstract 47: Caveolin-1 is Critical for Abdominal Aortic Aneurysm Induced by Angiotensin II Oral Session VI: Concurrent B Vascular Remodeling and Dysfunction
In conclusion, Cav1 and presumably vascular caveolae microdomains appear to play a critical role in the formation of AAA by Ang II via regulation of the ADAM17/EGFR signaling and subsequent ER/oxidative stress.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Obama, T., Takayanagi, T., Crawford, K. J., Kobayashi, T., Rizzo, V., Eguchi, S. Tags: Oral Session VI: Concurrent B Vascular Remodeling and Dysfunction Source Type: research
Abstract 419: Investigating the Role of Epidermal Growth Factor Receptors in Angiotensin II-induced Hypertrophic Signalling in Cardiomyocytes Poster Session II
Cardiac hypertrophy is characterized by stimulation of hypertrophic signalling pathways representing the reactivation of the ‘foetal gene program’ (hypertrophic genes) and activation of the MAPK pathway. Angiotensin II (AngII) stimulates cardiac hypertrophy, a process which may involve the transactivation of epidermal growth factor receptors (ErbBs). Three subtypes of ErbBs are present in the postnatal heart (ErbB1, 2, 4), yet their precise roles are poorly understood. We have shown that the ErbB4-selective ligand neuregulin 1 beta-1 (NRG1-β1) potently stimulates cardiomyocyte hypertrophy. We now aim to de...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Wang, Z., Chan, H.-W., Chen, C., Thomas, W. G., Paravicini, T. M. Tags: Poster Session II Source Type: research
Abstract 511: Endothelial Cell-specific Liver Kinase B1 Deletion Causes Hypertension in Mice in vivo Poster Session II
Conclusions- Our findings indicate that endothelial cell LKB1 plays an essential role in regulating eNOS activity, endothelial function, and blood pressure through modulating AMPK-mediated caveolin-1expression.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Zhang, W., Zou, M. Tags: Poster Session II Source Type: research
Transcriptional Regulation of Renal Dopamine D1 Receptor Function During Oxidative Stress Kidney
There exists a strong link between oxidative stress, renal dopaminergic system, and hypertension. It is reported that reactive oxygen species attenuate renal proximal tubular dopamine receptor (D1R) function, which disrupts sodium regulation and leads to hypertension. However, the mechanisms for renal D1R dysfunction are not clear. We investigated the role of redox-sensitive transcription factors AP1 and SP3 in transcriptional suppression of D1R gene and subsequent D1R signaling. Human kidney proximal tubular cells were treated with a pro-oxidant l-buthionine sulfoximine (BSO) with and without an antioxidant tempol. In hum...
Source: Hypertension - April 8, 2015 Category: Cardiology Authors: Banday, A. A., Lokhandwala, M. F. Tags: Animal models of human disease Kidney Source Type: research
Angiotensin II Activates the RhoA Exchange Factor Arhgef1 in Humans Renin-Angiotensin System
In conclusion, our results strongly suggest that Arhgef1 mediates Ang II–induced RhoA activation in humans. Moreover, they show that measurement of RhoA guanine exchange factor activity in peripheral blood mononuclear cells might be a useful method to evaluate RhoA guanine exchange factor activity in humans.
Source: Hypertension - May 13, 2015 Category: Cardiology Authors: Carbone, M. L., Bregeon, J., Devos, N., Chadeuf, G., Blanchard, A., Azizi, M., Pacaud, P., Jeunemaitre, X., Loirand, G. Tags: ACE/Angiotension receptors, Other hypertension, Other Vascular biology Renin-Angiotensin System Source Type: research
Abstract MP05: Knockdown of Gamma-adducin Expression Impairs the Myogenic Response of the Cerebral and Renal Arterioles Session Title: Vascular Biology/Remodeling and Dysfunction
We recently identified a region on chromosome 1 containing 15 genes that rescues the impaired myogenic response in the afferent arteriole (Af-art) and the development of renal injury in Fawn Hood Hypertensive (FHH) rats. We also found an inactivating K572Q mutation in the gamma-Adducin (Add3) gene in FHH rats in this region that may play a causal role. To test this hypothesis, the present study examed the effect of knockdown of the expression of Add3 with DsiRNA on the myogenic response of renal and cerebral arterioles. A newly designed 27-mer Add3 DsiRNA blocked the expression of the Add3 protein in 293 cells and reduced ...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Fan, F., Pabbidi, M. R., Ge, Y., Roman, R. J. Tags: Session Title: Vascular Biology/Remodeling and Dysfunction Source Type: research
Abstract P052: Homocysteine Increases Macrophage-Derived Paraoxonase -1 Expression Independent of CD68 Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Although atherosclerotic plaque rupture is the leading cause of myocardial infarction, the mechanisms are unclear. Macrophages burdened with oxidized LDL (oxLDL) become foam cells: hallmarks of plaque progression and instability. One of the main macrophage-specific receptors for oxLDL is CD68. Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated lactonase capable of retarding/inhibiting LDL oxidation. Elevated levels of homocysteine (Hcy), an amino acid homologue and independent cardiovascular risk factor, is metabolized by Pon1.Given the literature connections of oxLDL, Pon1, Hcy, and macrophages to atheros...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Chernyavskiy, I., Winchester, L., Veeranki, S., Tyagi, S. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research
