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Autophagy promotes fibrosis and apoptosis in the peritoneum during long ‐term peritoneal dialysis
In this study, we found that the coincidence of elevated TGF‐β1 expression, autophagy, apoptosis and fibrosis in peritoneal membrane from patients with peritoneal dialysis. The peritoneal membranes from patients were performed with immunocytochemistry and transmission electron microscopy. Human peritoneal mesothelial cells were treated with 1.5%, 2.5% and 4.25% HGPDS for 24 hrs; Human peritoneal mesothelial cells pre‐treated with TGF‐β1 (10 ng/ml) or transfected with siRNA Beclin1 were treated with 4.25% HGPDS or vehicle for 24 hrs. We further detected the production of TGF‐β1, activation of TGF‐β1/Smad2/3 si...
Source: Journal of Cellular and Molecular Medicine - October 27, 2017 Category: Molecular Biology Authors: Jingjing Wu, Changying Xing, Li Zhang, Huijuan Mao, Xuguan Chen, Mingxing Liang, Fang Wang, Haibin Ren, Hongqing Cui, Aiqin Jiang, Zibin Wang, Meijuan Zou, Yong Ji Tags: Original Article Source Type: research

BMP‐9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway
Abstract The process of vascular calcification shares many similarities with that of physiological skeletal mineralization, and involves the deposition of hydroxyapatite crystals in arteries. However, the cellular mechanisms responsible have yet to be fully explained. Bone morphogenetic protein (BMP‐9) has been shown to exert direct effects on both bone development and vascular function. In the present study, we have investigated the role of BMP‐9 in vascular smooth muscle cell (VSMC) calcification. Vessel calcification in chronic kidney disease (CKD) begins pre‐dialysis, with factors specific to the dialysis milieu ...
Source: Journal of Cellular and Molecular Medicine - October 9, 2014 Category: Molecular Biology Authors: Dongxing Zhu, Neil Charles Wallace Mackenzie, Catherine M. Shanahan, Rukshana C. Shroff, Colin Farquharson, Vicky Elisabeth MacRae Tags: Original Article Source Type: research