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The apolipoprotein A ‐I mimetic peptide, D‐4F, restrains neointimal formation through heme oxygenase‐1 up‐regulation
In conclusion, D‐4F inhibited VSMC proliferation and migration in vitro and neointimal formation in vivo through HO‐1 up‐regulation, which provided a novel prophylactic and therapeutic strategy for anti‐restenosis of arteries.
Source: Journal of Cellular and Molecular Medicine - July 1, 2017 Category: Molecular Biology Authors: Donghui Liu, Mengzhang Wu, Qian Du, Zhenzhen Ding, Mingming Qian, Zijia Tong, Wenqi Xu, Le Zhang, He Chang, Yan Wang, Caihua Huang, Donghai Lin Tags: Original Article Source Type: research

Zinc rescues obesity ‐induced cardiac hypertrophy via stimulating metallothionein to suppress oxidative stress‐activated BCL10/CARD9/p38 MAPK pathway
In this study, we investigated the mechanisms by which zinc inactivates p38 MAPK to prevent ORCH. Mice (4‐week old) were fed either high fat diet (HFD, 60% kcal fat) or normal diet (ND, 10% kcal fat) containing variable amounts of zinc (deficiency, normal and supplement) for 3 and 6 months. P38 MAPK siRNA and the p38 MAPK inhibitor SB203580 were used to suppress p38 MAPK activity in vitro and in vivo, respectively. HFD activated p38 MAPK and increased expression of B‐cell lymphoma/CLL 10 (BCL10) and caspase recruitment domain family member 9 (CARD9). These responses were enhanced by zinc deficiency and attenuated by zi...
Source: Journal of Cellular and Molecular Medicine - February 2, 2017 Category: Molecular Biology Authors: Shudong Wang, Junlian Gu, Zheng Xu, Zhiguo Zhang, Tao Bai, Jianxiang Xu, Jun Cai, Gregory Barnes, Qiu ‐Ju Liu, Jonathan H. Freedman, Yonggang Wang, Quan Liu, Yang Zheng, Lu Cai Tags: Original Article Source Type: research