The apolipoprotein A ‐I mimetic peptide, D‐4F, restrains neointimal formation through heme oxygenase‐1 up‐regulation

In conclusion, D‐4F inhibited VSMC proliferation and migration in vitro and neointimal formation in vivo through HO‐1 up‐regulation, which provided a novel prophylactic and therapeutic strategy for anti‐restenosis of arteries.

Source: Journal of Cellular and Molecular Medicine - July 1, 2017 Category: Molecular Biology Authors: Donghui Liu, Mengzhang Wu, Qian Du, Zhenzhen Ding, Mingming Qian, Zijia Tong, Wenqi Xu, Le Zhang, He Chang, Yan Wang, Caihua Huang, Donghai Lin Tags: Original Article Source Type: research