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Source: Phytomedicine

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Total 43 results found since Jan 2013.

Potent effects of dioscin against gastric cancer in vitro and in vivo
Conclusion Our works confirmed the activity of dioscin against gastric cancer. In addition, this work also provided that dioscin is a new potent candidate for treating gastric cancer in the future. Graphical abstract
Source: Phytomedicine - February 14, 2016 Category: Drugs & Pharmacology Source Type: research

Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells
Conclusions Consequently, marein improved insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein could be a promising leading compound for the development of hypoglycemic agent or developed as an adjuvant drug for diabetes mellitus. Graphical abstract
Source: Phytomedicine - May 18, 2016 Category: Drugs & Pharmacology Source Type: research

MHP-1 inhibits cancer metastasis and restores topotecan sensitivity via regulating epithelial-mesenchymal transition and TGF-β signaling in human breast cancer cells
Conclusion MHP-1 significantly inhibited breast cancer metastasis and restored drug sensitivity in TPT-resistant cells via down-regulation of TGF-β signaling and EMT program. The combination of non-toxic agents like MHP-1 and current anti-cancer drugs should be considered in the future treatment of cancer. Graphical abstract
Source: Phytomedicine - July 4, 2016 Category: Drugs & Pharmacology Source Type: research

Mistletoe (viscum album) extract targets Axl to suppress cell proliferation and overcome cisplatin- and erlotinib-resistance in non-small cell lung cancer cells.
Conclusion : Taken together, our data provide that VAE targets Axl to suppress cell proliferation and to circumvent cisplatin- and erlotinib-resistance in NSCLC cells. Graphical abstract
Source: Phytomedicine - September 29, 2017 Category: Drugs & Pharmacology Source Type: research

Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting RAS and TGF- β1/Smad axis
Conclusions This study demonstrated beneficial role of PZA in renal fibrosis and podocyte injury. Our study highlighted that PZA inhibits RAS and further suppresses TGFβ1/Smad pathway through inhibiting Smad2/3 phosphorylation via blocking Smad2/3-TGFβRI protein interaction. PZA is implicated in activation of RAS/TGFβ1/Smad axis in HK-2 cells and podocytes. PZA could be considered as a novel RAS inhibitor for treating CKD. Graphical abstract
Source: Phytomedicine - October 13, 2017 Category: Drugs & Pharmacology Source Type: research

G protein-coupled estrogen receptor is involved in the anti-inflammatory effects of genistein in microglia
Conclusion Taken together, these data provide the first evidence that genistein exerts anti-inflammatory effects in microglial cells via GPER activation. These beneficial effects of genistein may represent a new strategy for the treatment of neuroinflammatory diseases. Graphical abstract
Source: Phytomedicine - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3 β activity
Conclusion Rhein protects myocardial H9c2 cells against hypoxia/reoxygenation induced injury via AKT/ GSK3β/p38 pathway. Graphical abstract
Source: Phytomedicine - June 22, 2018 Category: Drugs & Pharmacology Source Type: research

HMQ-T-F5 (1-(4-(2-aminoquinazolin-7-yl)phenyl)-3-(2-bromo-5- (trifluoromethoxy)phenyl) thiourea) suppress proliferation and migration of human cervical HeLa cells via inhibiting Wnt/ β-catenin signaling pathway
Conclusion Our findings demonstrated that F5 can target β-catenin potentially and is useful in the treatment of cervical cancer. Graphical abstract
Source: Phytomedicine - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

HMQ-T-F5 (1-(4-(2-aminoquinazolin-7-yl)phenyl)-3-(2-bromo-5- (trifluoromethoxy)phenyl) thiourea) suppress proliferation and migration of human cervical HeLa cells via inhibiting Wnt/β-catenin signaling pathway
ConclusionOur findings demonstrated that F5 can target β-catenin potentially and is useful in the treatment of cervical cancer.Graphical abstract.
Source: Phytomedicine - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3β activity
ConclusionRhein protects myocardial H9c2 cells against hypoxia/reoxygenation induced injury via AKT/ GSK3β/p38 pathway.Graphical abstract
Source: Phytomedicine - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

HMQ-T-F5 (1-(4-(2-aminoquinazolin-7-yl)phenyl)-3-(2-bromo-5- (trifluoromethoxy)phenyl) thiourea) suppress proliferation and migration of human cervical HeLa cells via inhibiting Wnt/β-catenin signaling pathway
ConclusionOur findings demonstrated that F5 can target β-catenin potentially and is useful in the treatment of cervical cancer.Graphical abstract.
Source: Phytomedicine - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3β activity
ConclusionRhein protects myocardial H9c2 cells against hypoxia/reoxygenation induced injury via AKT/ GSK3β/p38 pathway.Graphical abstract
Source: Phytomedicine - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Contribution of human UDP-glucuronosyltransferases to the antioxidant effects of propolis, artichoke and silymarin
Conclusion: In conclusion, this study provides a possible molecular mechanism for protective antioxidant effects associated with the herbal drugs propolis, artichoke and silymarin. The herbal drug-mediated transcriptional upregulation of human detoxifying UGT1A enzymes via activation of AhR and Nrf2 leads to reduced hydrogen peroxide and oxidative stress. Because of UGT1A activation, the intake of these drugs could affect the therapeutic efficacy of other drugs when these also undergo metabolism by glucuronidation.Graphical abstract
Source: Phytomedicine - August 10, 2018 Category: Drugs & Pharmacology Source Type: research

Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway
ConclusionWe first demonstrated that ALO induced apoptosis and G2/M cell cycle arrest in HCC cells through inhibition of the PI3K/Akt signaling pathway. This study provides a rationale for ALO as a potential chemotherapeutic agent for HCC.Graphical abstract
Source: Phytomedicine - January 29, 2019 Category: Drugs & Pharmacology Source Type: research

Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/ Wnt inhibitory factor 1 (WIF1) axis
Conclusion: Taken together, we demonstrated that SFN could suppress the growth of NPC cells via the DNMT1/WIF1 axis.Graphical abstract
Source: Phytomedicine - July 30, 2019 Category: Drugs & Pharmacology Source Type: research