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Source: Phytomedicine
Condition: Diabetes Mellitus
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Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells
Conclusions Consequently, marein improved insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein could be a promising leading compound for the development of hypoglycemic agent or developed as an adjuvant drug for diabetes mellitus. Graphical abstract
Source: Phytomedicine - May 18, 2016 Category: Drugs & Pharmacology Source Type: research
