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Markers of Accelerated Skeletal Muscle Regenerative Response in MRL/MpJ Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors
This study suggests that a combination of MPCs and modulating antio xidative stress can represent a novel therapy to improve muscle healing after injury, disease, and aging.© AlphaMed Press 2018
Source: Stem Cells - December 10, 2018 Category: Stem Cells Authors: Chieh Tseng, Krishna Sinha, Haiying Pan, Yan Cui, Ping Guo, Chih Yi Lin, Fan Yang, Zhenhan Deng, Holger K. Eltzschig, Aiping Lu, Johnny Huard Tags: Regenerative Medicine Source Type: research

Slow ‐Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells
This article is protected by copyright. All rights reserved. Fiber‐type proportions are responsible for skeletal muscle properties including contractility, metabolism (glycolytic and oxidative), and fatigue resistance, as well as its susceptibility to disease conditions and its plasticity to respond to demands of exercise or disuse. The mechanism that restores the original muscle‐specific fiber‐type composition after a muscle regenerates from trauma or chemical insult is not well understood. Here we show that Sema3A ligand, which is secreted from resident myogenic stem satellite cells exclusively at the early‐diff...
Source: Stem Cells - May 7, 2017 Category: Stem Cells Authors: Ryuichi Tatsumi, Takahiro Suzuki, Mai ‐Khoi Q. Do, Yuki Ohya, Judy E. Anderson, Ayumi Shibata, Mai Kawaguchi, Shunpei Ohya, Hideaki Ohtsubo, Wataru Mizunoya, Shoko Sawano, Yusuke Komiya, Riho Ichitsubo, Koichi Ojima, Shin‐ichiro Nishimatsu, Tsutomu No Tags: Tissue ‐Specific Stem Cells Source Type: research

Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2 ‐Mediated Degradation of p53
Abstract Bre is a conserved cellular protein expressed in various tissues. Its major function includes DNA damage repair and anti‐apoptosis. Recent studies indicate that Bre is potentially involved in stem cell differentiation although pathophysiological significance along with the molecular mechanisms is still unclear. Here, we report that Bre protein was substantially expressed in the bone tissue and its expression was highly upregulated during the osteogenic differentiation. To test a hypothesis that Bre plays functional roles in the process of osteogenic differentiation, we examined the expression of Bre in an osteop...
Source: Stem Cells - April 24, 2017 Category: Stem Cells Authors: Fujun Jin, Yiliang Wang, Xiaojing Wang, Yanting Wu, Xiaoyan Wang, Qiuying Liu, Yexuan Zhu, Enqi Liu, Jianglin Fan, Yifei Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Focal Adhesion Kinase and Wnt Signaling Regulate Human Ductal Carcinoma In Situ Stem Cell Activity and Response to Radiotherapy
Abstract Cancer stem cells (CSCs) can avoid or efficiently repair DNA damage from radio and chemotherapy, which suggests they play a role in disease recurrence. Twenty percentage of patients treated with surgery and radiotherapy for ductal carcinoma in situ (DCIS) of the breast recur and our previous data show that high grade DCIS have increased numbers of CSCs. Here, we investigate the role of focal adhesion kinase (FAK) and Wnt pathways in DCIS stem cells and their capacity to survive irradiation. Using DCIS cell lines and patient samples, we demonstrate that CSC‐enriched populations are relatively radioresistant and p...
Source: Stem Cells - January 22, 2015 Category: Stem Cells Authors: Kathryn E. Williams, Nigel J. Bundred, Göran Landberg, Robert B. Clarke, Gillian Farnie Tags: Cancer Stem Cells Source Type: research

Selective interference targeting of lnk in umbilical cord‐derived late endothelial progenitor cells improves vascular repair, following hindlimb ischemic injury, via regulation of JAK2/STAT3 signaling
This article is protected by copyright. All rights reserved.
Source: Stem Cells - December 23, 2014 Category: Stem Cells Authors: Sang Hun Lee, Kyeung Bin Lee, Jun Hee Lee, Songhwa Kang, Hwi Gon Kim, Takayuki Asahara, Sang Mo Kwon Tags: Regenerative Medicine Source Type: research

Focal adhesion kinase and wnt signalling regulates human ductal carcinoma in situ stem cell activity and response to radiotherapy
Abstract Cancer stem cells (CSCs) can avoid or efficiently repair DNA damage from radio and chemotherapy, which suggests they play a role in disease recurrence. 20% of patients treated with surgery and radiotherapy for ductal carcinoma in Situ (DCIS) of the breast recur and our previous data shows that high grade DCIS have increased numbers of CSCs. Here, we investigate the role of Focal Adhesion Kinase (FAK) and Wnt pathways in DCIS stem cells and their capacity to survive irradiation. Using DCIS cell lines and patient samples we demonstrate that CSC‐enriched populations are relatively radioresistant and possess high FA...
Source: Stem Cells - September 3, 2014 Category: Stem Cells Authors: Kathryn E Williams, Nigel J Bundred, Göran Landberg, Robert B Clarke, Gillian Farnie Tags: Original Research Source Type: research