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Lead Neurotoxicity on Human Neuroblastoma Cell Line SH-SY5Y is Mediated via Transcription Factor EGR1/Zif268 Induced Disrupted in Scherophernia-1 Activation.
Abstract Lead (Pb2+) is a well-known type of neurotoxin and chronic exposure to Pb2+ induces cognition dysfunction. In this work, the potential role of early growth response gene 1 (EGR1) in the linkage of Pb2+ exposure and disrupted in scherophernia-1 (DISC1) activity was investigated. Human neuroblastoma cell line SH-SY5Y was subjected to different concentrations of lead acetate (PbAc) to determine the effect of Pb2+ exposure on the cell viability, apoptosis, and activity of EGR1 and DISC1. Then the expression of EGR1 in SH-SY5Y cells was knocked down with specific siRNA to assess the function of EGR1 in Pb2+ in...
Source: Neurochemical Research - June 4, 2018 Category: Neuroscience Authors: You Y, Peng B, Ben S, Hou W, Sun L, Jiang W Tags: Neurochem Res Source Type: research

Resveratrol Attenuates the Cytotoxicity Induced by Amyloid- β1-42 in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K/Akt/Nrf2 Pathway.
Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-β1-42 in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K/Akt/Nrf2 Pathway. Neurochem Res. 2017 Oct 31;: Authors: Hui Y, Chengyong T, Cheng L, Haixia H, Yuanda Z, Weihua Y Abstract Oxidative stress and cytotoxic damage induced by amyloid beta (Aβ) have been considered pivotal in the pathogenesis of Alzheimer's disease (AD) and may represent a target for treatment. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway elicits a survival signal to protect against multiple injuries, and the transcription factor nuclear factor erythroid 2...
Source: Neurochemical Research - October 31, 2017 Category: Neuroscience Authors: Hui Y, Chengyong T, Cheng L, Haixia H, Yuanda Z, Weihua Y Tags: Neurochem Res Source Type: research