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KLF9 regulates PRDX6 expression in hyperglycemia-aggravated bupivacaine neurotoxicity.
CONCLUSIONS: The results of this study demonstrated that hyperglycemia aggravated Bup neurotoxicity by upregulating KLF9 expression, which repressed the antioxidant PRDX6 and led to mitochondrial dysfunction, ROS burst, and cell death. Understanding this mechanism may, thus, offer valuable insights for the prevention and treatment of neurotoxicity induced by LAs, especially in diabetic patients. PMID: 33547545 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - February 5, 2021 Category: Biochemistry Authors: Li H, Weng Y, Lai L, Lei H, Xu S, Zhang Y, Li L Tags: Mol Cell Biochem Source Type: research

Beneficial effect of ER stress preconditioning in protection against FFA-induced adipocyte inflammation via XBP1 in 3T3-L1 adipocytes.
Abstract Adipose tissue inflammation is closely associated with the development of obesity and insulin resistance. Free fatty acids (FFAs) are a major inducer of obesity-related insulin resistance. Previously, we reported that endoplasmic reticulum (ER) stress potentially mediated retinal inflammation in diabetic retinopathy. The unfolded protein response (UPR) protects cells against damage induced by oxidative stress. X-box binding protein 1 (XBP1) plays a major role in protecting cells by modulating the UPR. However, the link between ER stress and adipocyte inflammation has been poorly investigated. In the prese...
Source: Molecular and Cellular Biochemistry - October 15, 2019 Category: Biochemistry Authors: Wang M, Chen X, Zheng Z, Yu S, Zhou B, Liu Y, Liu D, Chen Y, Qian X Tags: Mol Cell Biochem Source Type: research

Phosphorylation of TSC2 by PKC- δ reveals a novel signaling pathway that couples protein synthesis to mTORC1 activity.
Phosphorylation of TSC2 by PKC-δ reveals a novel signaling pathway that couples protein synthesis to mTORC1 activity. Mol Cell Biochem. 2019 Jan 25;: Authors: Zhan J, Chitta RK, Harwood FC, Grosveld GC Abstract Downstream of insulin-like growth factor receptor, the TSC1/2/ TCB1D7 (tuberous sclerosis complex) and mTOR (mechanistic target of rapamycin) pathways are implicated in many human diseases, including cancer and diabetes. Targeting this pathway is currently an important approach for palliating or eradicating cancer. Downstream of mTOR, translational machinery targeting holds great promise for a...
Source: Molecular and Cellular Biochemistry - January 25, 2019 Category: Biochemistry Authors: Zhan J, Chitta RK, Harwood FC, Grosveld GC Tags: Mol Cell Biochem Source Type: research

Manganese supplementation increases adiponectin and lowers ICAM-1 and creatinine blood levels in Zucker type 2 diabetic rats, and downregulates ICAM-1 by upregulating adiponectin multimerization protein (DsbA-L) in endothelial cells.
This study investigates the hypothesis that the beneficial effects of Mn supplementation are mediated by adiponectin and DsbA-L. At 6 weeks of age, Male Zucker diabetic fatty rats (ZDF) were randomly divided into two groups: diabetic controls and Mn-supplemented diabetic rats. Each rat was supplemented with Mn (D+Mn, 16 mg/kg BW) or water (placebo, D+P) daily for 7 weeks by oral gavage. For cell culture studies, Human Umbilical Vein Endothelial Cells (HUVEC) or 3T3L1 adipocytes were pretreated with Mn (0-10 µM MnCl2) for 24 h, followed by high glucose (HG, 25 mM) or normal glucose (5 mM) exposure for another 24 h. M...
Source: Molecular and Cellular Biochemistry - January 12, 2017 Category: Biochemistry Authors: Burlet E, Jain SK Tags: Mol Cell Biochem Source Type: research

Specific MAPK inhibitors prevent hyperglycemia-induced renal diseases in type 1 diabetic mouse model.
Abstract Mitogen-activated protein kinase (MAPK) and renin-angiotensin system (RAS) play critical roles in the process of renal diseases, but their interaction has not been comprehensively discussed. In the present studies, we investigated the renoprotective effects of MPAK inhibitors on renal diseases in type 1 diabetic mouse model, and clarify the crosstalk among MAPK signaling. Type 1 diabetic mouse model was established in male C57BL/6 J mice, and treated with or without 10 mg/kg MAPK blockers, including ERK inhibitor PD98059, p38 inhibitor SB203850, and JNK inhibitor SP600125 for four weeks. Hyperglycemia i...
Source: Molecular and Cellular Biochemistry - July 6, 2016 Category: Biochemistry Authors: Hong Z, Hong Z, Wu D, Nie H Tags: Mol Cell Biochem Source Type: research

MEK/ERK pathway activation by insulin receptor isoform alteration is associated with the abnormal proliferation and differentiation of intestinal epithelial cells in diabetic mice.
Abstract In previous studies, we have reported the abnormal proliferation and differentiation of intestinal epithelial cells (IECs) in diabetes mellitus (DM) mice. The insulin receptor (IR) and its downstream mitogen-activated protein kinase kinase (MAPKK also known as MEK)/extracellular-regulated protein kinase (ERK) pathway is a classic pathway associated with cell proliferation and differentiation. The purpose of the present study is to investigate the role of the MEK/ERK pathway in abnormal proliferation and differentiation of IECs in DM mice. DM mouse models were induced by intraperitoneal injection of strept...
Source: Molecular and Cellular Biochemistry - January 2, 2016 Category: Biochemistry Authors: Ouyang H, Yang HS, Yu T, Shan TD, Li JY, Huang CZ, Zhong W, Xia ZS, Chen QK Tags: Mol Cell Biochem Source Type: research

Taurine prevents high glucose-induced angiopoietin-2/tie-2 system alterations and apoptosis in retinal microvascular pericytes.
Abstract Previously, we confirmed that taurine prevented diabetes-induced apoptosis in retinal glial cells via its anti-oxidation and anti-glutamate excitotoxicity mechanisms. The aim of this study is to investigate the effects of taurine on angiopoietin-2 (Ang-2)/Tie-2 system expressions and apoptosis in high glucose-treated retinal microvascular pericytes (RMPs). Also, the possible mechanism involved in the inhibition of taurine on RMPs apoptosis is investigated. The expressions of Ang-2, Tie-2 were detected by qRT-PCR and ELISA. The level of phosphorylated Tie-2 (P-Tie-2) was examined by ELISA. Hoechst 33342 an...
Source: Molecular and Cellular Biochemistry - July 25, 2014 Category: Biochemistry Authors: Zeng K, Ming J, Yang N, Wang J, Yu X, Song Y, Yang Y Tags: Mol Cell Biochem Source Type: research