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Source: Molecular and Cellular Biochemistry
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Total 162 results found since Jan 2013.
PICK1 modulates glycolysis and angiogenesis of hypoxic endothelial cells by regulating iron homeostasis
Mol Cell Biochem. 2023 Jun 27. doi: 10.1007/s11010-023-04795-z. Online ahead of print.ABSTRACTIron accumulation, which is controlled by transferrin receptor 1 (TfR1), modulates hypoxia-inducible factor-1α (HIF-1α) activation and angiogenesis of hypoxic endothelial cells. The study examined the role of protein interacting with C-kinase 1 (PICK1), a scaffold protein containing PDZ domain, in regulating glycolysis and angiogenesis of hypoxic vascular endothelial cells through its potential effect on TfR1, which features a supersecondary structure that interacts with the PDZ domain. Iron chelator deferoxamine and TfR1 siRNA ...
Source: Molecular and Cellular Biochemistry - June 27, 2023 Category: Biochemistry Authors: Yu Cao Hongbo Wang Shuyu Hu Qiaomin Xu Jun Ma Huile Wang Xiangqing Xiong Wantie Wang Liangrong Wang Source Type: research
Multimerin 1 aids in the progression of ovarian cancer possibly via modulation of DNA damage response and repair pathways
Mol Cell Biochem. 2023 Feb 1. doi: 10.1007/s11010-023-04668-5. Online ahead of print.ABSTRACTOvarian cancer is one of the leading causes of deaths among women. Despite advances in the treatment regimes, a high rate of diagnosis in the advanced stage makes it almost an incurable malignancy. Thus, more research efforts are required to identify potential molecular markers for early detection of the disease and therapeutic targets to augment the survival rate of ovarian cancer patients. Previously, in this context, we identified dysregulated expression of multimerin 1 (MMRN1) in ovarian cancer. To elucidate the relationship be...
Source: Molecular and Cellular Biochemistry - February 1, 2023 Category: Biochemistry Authors: Abhinav Saini Vikrant Kumar Anil Kumar Tomar Alpana Sharma Savita Yadav Source Type: research
Retraction Note: Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA
Mol Cell Biochem. 2022 Oct 17. doi: 10.1007/s11010-022-04567-1. Online ahead of print.NO ABSTRACTPMID:36251172 | DOI:10.1007/s11010-022-04567-1
Source: Molecular and Cellular Biochemistry - October 17, 2022 Category: Biochemistry Authors: Jingchun Wang Weifeng Ding Baolan Sun Rongrong Jing Hua Huang Gongsheng Shi Huimin Wang Source Type: research
Chrysin protects cardiac H9c2 cells against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced endoplasmic reticulum stress by up-regulating the Nrf2/PERK pathway
Mol Cell Biochem. 2022 Aug 9. doi: 10.1007/s11010-022-04531-z. Online ahead of print.ABSTRACTOxidative and endoplasmic reticulum (ER) stress-mediated cardiac apoptosis is an essential pathological process in cardiovascular diseases (CVDs). Chrysin (Chy) is a natural flavonoid that exerts several health benefits, particularly anti-oxidative and anti-apoptotic effects. However, its protective effect against CVDs and its mechanism of action at a molecular level remains unclear. Therefore, the present study aimed to investigate the interaction of ER stress response protein with Chy by computational analysis and molecular actio...
Source: Molecular and Cellular Biochemistry - August 9, 2022 Category: Biochemistry Authors: Subramani Yuvaraj Arumugam Kalaiselvi Ajeeth Shanavas Syed Mohamed Puhari Albert Abhishek Tharmarajan Ramprasath Varadaraj Vasudevan Narasimman Vignesh Govindan Sadasivam Selvam Source Type: research
SIRT1 regulates mitotic catastrophe via autophagy and BubR1 signaling
Mol Cell Biochem. 2022 May 31. doi: 10.1007/s11010-022-04470-9. Online ahead of print.ABSTRACTMitotic catastrophe (MC) is a suppressive mechanism that mediates the elimination of mitosis-deficient cells through apoptosis, necrosis or senescence after M phase block. SIRT1 is involved in the regulation of several cellular processes, including autophagy. However, the relationship between SIRT1 and MC has been largely obscure. Our study highlights that SIRT1 might be involved in the regulation of MC. We have shown that degradation of the SIRT1 protein via proteasome and lysosomal pathway was accompanied by MC induced via BMH-2...
Source: Molecular and Cellular Biochemistry - May 31, 2022 Category: Biochemistry Authors: Weiwei Zhao Qing Wang Le Li Chengshen Xie Yequn Wu Mayank Gautam Lijia Li Source Type: research
miR-874-3p mitigates cisplatin resistance through modulating NF- κB/inhibitor of apoptosis protein signaling pathway in epithelial ovarian cancer cells
Mol Cell Biochem. 2021 Oct 30. doi: 10.1007/s11010-021-04271-6. Online ahead of print.ABSTRACTThe resistance to cisplatin, the most common platinum chemotherapy drug, may confine the efficacy of treatment in epithelial ovarian cancer patients. Aberrant expression of inhibitor of apoptosis proteins set the stage for resistance to cisplatin in EOC; besides, chemosensitivity in EOC can be chalked up to dysregulation of specific miRNAs. Herein, we investigated whether there is a potential correlation between miR-874-3p and the X-chromosome-linked inhibitor of apoptosis, a member of the IAP protein family in cisplatin-resistant...
Source: Molecular and Cellular Biochemistry - October 30, 2021 Category: Biochemistry Authors: Ying Wang Chenming Yan Junxia Qi Chunyan Liu Juan Yu Huabin Wang Source Type: research
Perturbed ER homeostasis by IGF-IIR α promotes cardiac damage under stresses
In this study, we investigate the molecular mechanism and contribution of IGF-IIRα in endoplasmic reticulum stress induction in the heart under doxorubicin-induced cardiotoxicity. Using in vitro H9c2 cells, in vivo transgenic rat cardiac tissues, siRNAs against CHOP, chemical ER chaperone PBA, and western blot experiments, we found that IGF-IIRα overexpression enhanced ER stress markers ATF4, ATF6, IRE1α, and PERK which were further aggravated by DOX treatment. This was accompanied by a significant perturbation in stress-associated MAPKs such as p38 and JNK. Interestingly, PARKIN, a stress responsive cellular protective...
Source: Molecular and Cellular Biochemistry - September 29, 2021 Category: Biochemistry Authors: Sudhir Pandey Chia-Hua Kuo William Shao-Tsu Chen Yu-Lan Yeh Wei-Wen Kuo Ray-Jade Chen Cecilia Hsuan Day Pei-Ying Pai Tsung-Jung Ho Chih-Yang Huang Source Type: research
