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Beneficial effect of ER stress preconditioning in protection against FFA-induced adipocyte inflammation via XBP1 in 3T3-L1 adipocytes.
Abstract Adipose tissue inflammation is closely associated with the development of obesity and insulin resistance. Free fatty acids (FFAs) are a major inducer of obesity-related insulin resistance. Previously, we reported that endoplasmic reticulum (ER) stress potentially mediated retinal inflammation in diabetic retinopathy. The unfolded protein response (UPR) protects cells against damage induced by oxidative stress. X-box binding protein 1 (XBP1) plays a major role in protecting cells by modulating the UPR. However, the link between ER stress and adipocyte inflammation has been poorly investigated. In the prese...
Source: Molecular and Cellular Biochemistry - October 15, 2019 Category: Biochemistry Authors: Wang M, Chen X, Zheng Z, Yu S, Zhou B, Liu Y, Liu D, Chen Y, Qian X Tags: Mol Cell Biochem Source Type: research

Estrogen-independent role of ER α in ovarian cancer progression induced by leptin/Ob-Rb axis.
In conclusion, our findings demonstrated that ERα, but not ERβ, is involved in leptin-induced ovarian cancer in an E2-independent manner, providing new evidence for cancer progression in obesity-associated ovarian cancer. PMID: 31077012 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - May 9, 2019 Category: Biochemistry Authors: Ghasemi A, Saeidi J, Mohtashami M, Hashemy SI Tags: Mol Cell Biochem Source Type: research

B cell translocation gene 2 (Btg2) is regulated by Stat3 signaling and inhibits adipocyte differentiation.
Abstract Btg2, a member of a family of antiproliferative proteins, is involved in downregulation of the JAK2-Stat3 signaling pathway. Here, we present evidence that the inhibitory effect of Btg2 on adipogenesis is suppressed by the proadipogenic activity of the Stat3 signaling pathway. Btg2 expression fluctuates during adipogenic differentiation of preadipocytes. Btg2 is also expressed at different levels in fat tissues from lean and obese mice. Furthermore, knockdown of Btg2 expression enhanced lipid accumulation and upregulated the expression of adipogenic marker genes. To gain insights into the molecular mechan...
Source: Molecular and Cellular Biochemistry - January 6, 2016 Category: Biochemistry Authors: Kim S, Hong JW, Park KW Tags: Mol Cell Biochem Source Type: research