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KLF9 regulates PRDX6 expression in hyperglycemia-aggravated bupivacaine neurotoxicity.
CONCLUSIONS: The results of this study demonstrated that hyperglycemia aggravated Bup neurotoxicity by upregulating KLF9 expression, which repressed the antioxidant PRDX6 and led to mitochondrial dysfunction, ROS burst, and cell death. Understanding this mechanism may, thus, offer valuable insights for the prevention and treatment of neurotoxicity induced by LAs, especially in diabetic patients. PMID: 33547545 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - February 5, 2021 Category: Biochemistry Authors: Li H, Weng Y, Lai L, Lei H, Xu S, Zhang Y, Li L Tags: Mol Cell Biochem Source Type: research

Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic acid via suppression of the long non-coding RNA HIF1A-AS1 in vitro.
This study investigated the effects of clopidogrel on palmitic acid-induced damage of human vascular endothelial cells (HUVECs), and the molecular mechanisms of LncRNA HIF1A-AS1 in regulating the proliferation and apoptosis of HUVECs in vitro. We firstly established a damage model of HUVECs through palmitic acid (PA) treatment. And the effect of clopidogrel reducing PA-induced apoptosis of HUVECs was observed by the flow cytometric measurement. To further understand the molecular mechanism of clopidogrel rescues PA-induced apoptosis, we used human LncRNA PCR array to compare the LncRNA expression profile difference between...
Source: Molecular and Cellular Biochemistry - March 12, 2015 Category: Biochemistry Authors: Wang J, Chen L, Li H, Yang J, Gong Z, Wang B, Zhao X Tags: Mol Cell Biochem Source Type: research