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Retraction Note: Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA
Mol Cell Biochem. 2022 Oct 17. doi: 10.1007/s11010-022-04567-1. Online ahead of print.NO ABSTRACTPMID:36251172 | DOI:10.1007/s11010-022-04567-1
Source: Molecular and Cellular Biochemistry - October 17, 2022 Category: Biochemistry Authors: Jingchun Wang Weifeng Ding Baolan Sun Rongrong Jing Hua Huang Gongsheng Shi Huimin Wang Source Type: research

Activation of EMT in colorectal cancer by MTDH/NF- κB p65 pathway.
This study tries to investigate the effect of MTDH gene up-regulation on the activation of EMT in colorectal cancer (CRC) cells and identify the role of NF-κB p65. The CaCO2 cells were divided into three groups: one control group of cultured CaCO2 cells (C1), and two groups of CaCO2 cells co-transfected using human MTDH expression plasmid with either siRNA targeting human NF-κB p65 or its negative control (C2 and C3 respectively). The gene modification was confirmed by qPCR and the effect of gene modification on CRC aggravation was studied. MTDH up-regulation significantly promoted CRC cell proliferation, activated anaer...
Source: Molecular and Cellular Biochemistry - February 28, 2019 Category: Biochemistry Authors: El-Ashmawy NE, El-Zamarany EA, Khedr EG, Abo-Saif MA Tags: Mol Cell Biochem Source Type: research

GADD45α modulates curcumin sensitivity through c-Abl- and JNK-dependent signaling pathways in a mismatch repair-dependent manner.
In this report, we show that the protein levels of gadd45α, whose transcript levels are increased during DNA damage and stress signals, are upregulated following curcumin treatment in a dose- and time-dependent manner. We further observed that cells compromised for Mlh1 function (HCT116 + Ch2) displayed ~twofold increased GADD45α upregulation compared to similarly treated proficient counterparts (HCT116 + Ch3). Similarly, suppression of Mlh1 using ShRNA increased GADD45α upregulation upon curcumin treatment. On the other hand, suppression of GADD45α using SiRNA-blocked curcumin-induced cell death induction in Mlh1-...
Source: Molecular and Cellular Biochemistry - January 30, 2016 Category: Biochemistry Authors: Naick H, Jin S, Baskaran R Tags: Mol Cell Biochem Source Type: research

AP4 activates cell migration and EMT mediated by p53 in MDA-MB-231 breast carcinoma cells.
Abstract Tumor metastasis is the primary cause of mortality in most cancer patients. Before disassociation from the tumors, most of malignant tumor cells undergo the epithelial-mesenchymal transition to break away from the adhesions between the cells and the surrounding extracellular matrix. Recently, activating enhancer-binding protein (AP4) has been shown to be a mediator of EMT in colorectal cancer and high level of AP4 correlates with poor prognosis in cancer patients. It has been found that AP4 upregulates the genes involved in EMT and cell proliferation in colorectal cancer cells and that the aggressive hum...
Source: Molecular and Cellular Biochemistry - June 3, 2015 Category: Biochemistry Authors: Chen S, Chiu SK Tags: Mol Cell Biochem Source Type: research

CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway.
Abstract CXCL13, an inflammatory factor in the microenvironment, plays a vital role in the progression of inflammatory diseases and tumors. CXCL13 and its receptor CXCR5 have been reported to be associated with poor prognosis of advanced colon cancer. However, the molecular mechanisms of CXCL13-CXCR5 axis in colon cancer remain elusive. The aim of this study was to investigate the role of CXCR5-CXCL13 axis in the growth and invasion of colon cancer cells. Our results showed that CXCL13 promoted the growth, migration, and matrigel invasion of colon cancer cells. Furthermore, CXCL13 increased the expression and secr...
Source: Molecular and Cellular Biochemistry - December 5, 2014 Category: Biochemistry Authors: Zhu Z, Zhang X, Guo H, Fu L, Pan G, Sun Y Tags: Mol Cell Biochem Source Type: research

MicroRNA-135b regulates metastasis suppressor 1 expression and promotes migration and invasion in colorectal cancer.
In this study, we evaluated the role of miR-135b in colorectal cancer (CRC) and its regulatory role for metastasis suppressor-1 (MTSS1) and its mechanisms. The levels of miR-135b and MTSS1 gene expression in 35 CRC and corresponding cancer-adjacent tissues, 27 colorectal adenoma, and 16 normal tissue samples were quantified using qRT-PCR and western blot analysis. The effect of miR-135b on MTSS1 expression was assessed by miR-135b mimics or inhibitor transfection to deregulate miR-135b expression. The direct interaction between them was verified by 3'-UTR dual-luciferase reporter assay. Furthermore, the roles of miR-135b i...
Source: Molecular and Cellular Biochemistry - December 17, 2013 Category: Biochemistry Authors: Wu W, Wang Z, Yang P, Yang J, Liang J, Chen Y, Wang H, Wei G, Ye S, Zhou Y Tags: Mol Cell Biochem Source Type: research

APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-β1/ERK signaling pathway in human colorectal cancer cells.
Abstract It is well documented that a proliferation-inducing ligand (APRIL), a newly found member of tumor necrosis factor superfamily, overexpressed in the majority of malignancies, plays a potential role in the occurrence and development of these tumors. Herein, we demonstrated that APRIL depletion by using RNA interference in human colorectal cancer (CRC) COLO 205 and SW480 cells resulted in cell proliferation inhibition and evoked cell cycle arrest in G0/G1 phase and apoptosis, coupled with decrease in CDK2, Cyclin D1, Bcl-2 expression and an increase of p21 and Bax expression. In addition, the decreased expre...
Source: Molecular and Cellular Biochemistry - July 20, 2013 Category: Biochemistry Authors: Wang F, Chen L, Ni H, Wang G, Ding W, Cong H, Ju S, Yang S, Wang H Tags: Mol Cell Biochem Source Type: research