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Source: Molecular and Cellular Biochemistry
Cancer: Cancer
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Total 62 results found since Jan 2013.
Multimerin 1 aids in the progression of ovarian cancer possibly via modulation of DNA damage response and repair pathways
Mol Cell Biochem. 2023 Feb 1. doi: 10.1007/s11010-023-04668-5. Online ahead of print.ABSTRACTOvarian cancer is one of the leading causes of deaths among women. Despite advances in the treatment regimes, a high rate of diagnosis in the advanced stage makes it almost an incurable malignancy. Thus, more research efforts are required to identify potential molecular markers for early detection of the disease and therapeutic targets to augment the survival rate of ovarian cancer patients. Previously, in this context, we identified dysregulated expression of multimerin 1 (MMRN1) in ovarian cancer. To elucidate the relationship be...
Source: Molecular and Cellular Biochemistry - February 1, 2023 Category: Biochemistry Authors: Abhinav Saini Vikrant Kumar Anil Kumar Tomar Alpana Sharma Savita Yadav Source Type: research
Retraction Note: Targeting of colorectal cancer growth, metastasis, and anti-apoptosis in BALB/c nude mice via APRIL siRNA
Mol Cell Biochem. 2022 Oct 17. doi: 10.1007/s11010-022-04567-1. Online ahead of print.NO ABSTRACTPMID:36251172 | DOI:10.1007/s11010-022-04567-1
Source: Molecular and Cellular Biochemistry - October 17, 2022 Category: Biochemistry Authors: Jingchun Wang Weifeng Ding Baolan Sun Rongrong Jing Hua Huang Gongsheng Shi Huimin Wang Source Type: research
SIRT1 regulates mitotic catastrophe via autophagy and BubR1 signaling
Mol Cell Biochem. 2022 May 31. doi: 10.1007/s11010-022-04470-9. Online ahead of print.ABSTRACTMitotic catastrophe (MC) is a suppressive mechanism that mediates the elimination of mitosis-deficient cells through apoptosis, necrosis or senescence after M phase block. SIRT1 is involved in the regulation of several cellular processes, including autophagy. However, the relationship between SIRT1 and MC has been largely obscure. Our study highlights that SIRT1 might be involved in the regulation of MC. We have shown that degradation of the SIRT1 protein via proteasome and lysosomal pathway was accompanied by MC induced via BMH-2...
Source: Molecular and Cellular Biochemistry - May 31, 2022 Category: Biochemistry Authors: Weiwei Zhao Qing Wang Le Li Chengshen Xie Yequn Wu Mayank Gautam Lijia Li Source Type: research
miR-874-3p mitigates cisplatin resistance through modulating NF- κB/inhibitor of apoptosis protein signaling pathway in epithelial ovarian cancer cells
Mol Cell Biochem. 2021 Oct 30. doi: 10.1007/s11010-021-04271-6. Online ahead of print.ABSTRACTThe resistance to cisplatin, the most common platinum chemotherapy drug, may confine the efficacy of treatment in epithelial ovarian cancer patients. Aberrant expression of inhibitor of apoptosis proteins set the stage for resistance to cisplatin in EOC; besides, chemosensitivity in EOC can be chalked up to dysregulation of specific miRNAs. Herein, we investigated whether there is a potential correlation between miR-874-3p and the X-chromosome-linked inhibitor of apoptosis, a member of the IAP protein family in cisplatin-resistant...
Source: Molecular and Cellular Biochemistry - October 30, 2021 Category: Biochemistry Authors: Ying Wang Chenming Yan Junxia Qi Chunyan Liu Juan Yu Huabin Wang Source Type: research
Effects of miR-202-5p silencing PIK3CA gene expression on proliferation, invasion, and epithelial-mesenchymal transition of cervical cancer SiHa cells through inhibiting PI3K/Akt/mTOR signaling pathway activation
In conclusion, the overexpression of miR-202-5p can suppress PIK3CA gene expression and the activation of PI3K/Akt/mTOR signaling pathway to suppress the proliferation, invasion, and EMT of cervical cancer.PMID:34244973 | DOI:10.1007/s11010-021-04211-4
Source: Molecular and Cellular Biochemistry - July 10, 2021 Category: Biochemistry Authors: Yan Zheng Lei Xie Shuwen Xu Weidong Yan Hongzhen Zhang Yali Meng Jingqiao Liu Xujing Wei Source Type: research
Activation of STING inhibits cervical cancer tumor growth through enhancing the anti-tumor immune response.
In this study, we found that the cGAS (Cyclic GMP-AMP synthase)/STING signal decreased in cervical cancer cells. Knockdown of STING by siRNA enhanced the cell viability and migration of cervical cancer cells, while activation of STING by ADU-S100 inhibited the cell viability of cervical cancer cells, with no effect on the migration and apoptosis. In addition, ADU-S100 promoted the secretion of IFNβ and IL-6, and the activation of TBK1 (TANK-binding kinase 1)/NF-κB (nuclear factor kappa-B) pathway. Meanwhile, knockdown of STING inhibited the production of IFNβ and IL-6 that were triggered by dsDNA and suppressed the TBK1...
Source: Molecular and Cellular Biochemistry - November 3, 2020 Category: Biochemistry Authors: Shi F, Su J, Wang J, Liu Z, Wang T Tags: Mol Cell Biochem Source Type: research
