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Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1 and TLR6.
Abstract Bacteria often infect the endometrium of cattle to cause endometritis, uterine disease and infertility. Lipopeptides are commonly found amongst bacteria and are detected by the Toll-like receptor (TLR) cell surface receptor TLR2 on immune cells. Heterodimers of TLR2 with TLR1 or TLR6 activate MAPK and NFκB intracellular signaling pathways to stimulate inflammatory responses. In the endometrium, epithelial and stromal cells are the first to encounter invading bacteria, so the present study explored whether endometrial cells can also mount inflammatory responses to bacterial lipopeptides via TLRs. The supe...
Source: Endocrinology - January 17, 2014 Category: Endocrinology Authors: Turner ML, Cronin JG, Healey GD, Sheldon IM Tags: Endocrinology Source Type: research

Pathogen-associated molecular patterns initiate inflammation and perturb the endocrine function of bovine granulosa cells from ovarian dominant follicles via TLR2 and TLR4 pathways.
In conclusion, bacterial PAMPs initiate inflammation and perturb the endocrine function of bovine granulosa cells from dominant follicles via TLR2 and TLR4 pathways.Précis: A rapid inflammatory response to pathogen-associated molecular patterns mediated by TLR2 and TLR4 pathways in granulosa cells provides a molecular explanation of how bacterial infections distant to the ovary can perturb dominant follicle function. PMID: 23825132 [PubMed - as supplied by publisher]
Source: Endocrinology - July 3, 2013 Category: Endocrinology Authors: Price JC, Bromfield JJ, Sheldon IM Tags: Endocrinology Source Type: research