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Long Noncoding RNA MIAT Modulates the Extracellular Matrix Deposition in Leiomyomas by Sponging MiR-29 Family
The objective of this study was to determine the expression and functional role of a long noncoding RNA (lncRNA) MIAT (myocardial infarction associated transcript) in leiomyoma pathogenesis. Leiomyoma as compared with myometrium (N=66) expressed significantly more MIAT which was independent of race/ethnicity and menstrual cycle phase but dependent on MED12 (mediator complex subunit 12) mutation status. Leiomyomas bearing the MED12 mutation expressed higher levels of MIAT and lower levels of microRNA 29 family (miR-29a, -b and -c) compared with MED12 wild type leiomyomas. Using luciferase reporter activity and RNA immunopre...
Source: Endocrinology - September 7, 2021 Category: Endocrinology Authors: Tsai-Der Chuang Derek Quintanilla Drake Boos Omid Khorram Source Type: research