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Source: Biomaterials

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Total 156 results found since Jan 2013.

Dual targeted delivery of statins and nucleic acids by chitosan-based nanoparticles for enhanced antiatherosclerotic efficacy
Biomaterials. 2021 Dec 15;280:121324. doi: 10.1016/j.biomaterials.2021.121324. Online ahead of print.ABSTRACTCardiovascular disease caused by atherosclerosis is a leading cause of morbidity and mortality worldwide. Owing to the synergistic regulation of cholesterol metabolism and lesion inflammation, the simultaneous administration of statins and nucleic acids is expected to alleviate atherosclerosis. In this work, we prepared atorvastatin- and galactose-modified trimethyl chitosan nanoparticles (GTANPs) with dual targeting to hepatocytes and lesional macrophages for encapsulating Baf60a siRNA (siBaf60a) and anti-miR-33 pD...
Source: Biomaterials - December 21, 2021 Category: Materials Science Authors: Ting Jiang Lu Xu Mengxin Zhao Fei Kong Xinrong Lu Cui Tang Chunhua Yin Source Type: research

Corrigendum to "Co-delivery of HIF1 α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer" Biomaterials 46 (2015) 13-25
Biomaterials. 2021 Dec 7;280:121296. doi: 10.1016/j.biomaterials.2021.121296. Online ahead of print.NO ABSTRACTPMID:34890971 | DOI:10.1016/j.biomaterials.2021.121296
Source: Biomaterials - December 10, 2021 Category: Materials Science Authors: Xiao Zhao Feng Li Yiye Li Hai Wang He Ren Jing Chen Guangjun Nie Jihui Hao Source Type: research

Reduction-responsive RNAi nanoplatform to reprogram tumor lipid metabolism and repolarize macrophage for combination pancreatic cancer therapy
Biomaterials. 2021 Nov 19:121264. doi: 10.1016/j.biomaterials.2021.121264. Online ahead of print.ABSTRACTPancreatic cancer (PAC) is one of the most lethal malignant neoplasms with poor prognosis and high mortality. Emerging evidence has revealed that abnormal tumor lipid metabolism and tumor-associated macrophages (TAMs) significantly contribute to PAC development and progression. Therefore, concurrently reprogramming tumor lipid metabolism and regulating TAMs function could be a promising strategy for effective PAC therapy. Herein, we identified an important enzyme catabolizing lipids (monoacylglycerol lipase, MGLL) and a...
Source: Biomaterials - November 26, 2021 Category: Materials Science Authors: Shuwen Cao Phei Er Saw Qian Shen Rong Li Yun Liu Xiaoding Xu Source Type: research

MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice
Biomaterials. 2021 Oct 11;278:121183. doi: 10.1016/j.biomaterials.2021.121183. Online ahead of print.ABSTRACTThe changes of small intestinal homeostasis have been recognized to contribute essentially to the obese development. However, the core small intestinal regulator which mediates over-nutrient impacts on the homeostasis of the small intestines remains elusive. Here, we identify the MMP-12 as such a responsive factor in mouse small intestines. Taking advantages of the nano delivery system, we demonstrate that small intestine-specific MMP-12 knockdown alleviates high-fat diet feeding-induced metabolic disorders and impr...
Source: Biomaterials - October 15, 2021 Category: Materials Science Authors: Mingming Song Shiyao Zhang Zixuan Tao Jianning Li Yujie Shi Yonghong Xiong Wenxiang Zhang Chang Liu Siyu Chen Source Type: research

M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages
In this study, we harnessed M1 macrophage-derived exosomes engineered to foster M1 polarization and target IL4R for the inhibition of tumor growth by reprogramming TAMs into M1-like macrophages. M1 exosomes were transfected with NF-κB p50 siRNA and miR-511-3p to enhance M1 polarization and were surface-modified with IL4RPep-1, an IL4R-binding peptide, to target the IL4 receptor of TAMs (named IL4R-Exo(si/mi). IL4R-Exo(si/mi) were internalized and downregulated target gens in M2 macrophages and decreased M2 markers, while increasing M1 markers, more efficiently compared with untargeted and control peptide-labeled exosomes ...
Source: Biomaterials - September 24, 2021 Category: Materials Science Authors: Gowri Rangaswamy Gunassekaran Sri Murugan Poongkavithai Vadevoo Moon-Chang Baek Byungheon Lee Source Type: research

Silica-coated calcium phosphate nanoparticles for gene silencing of NF- κB p65 by siRNA and their impact on cellular players of inflammation
Biomaterials. 2021 Jul 7;276:121013. doi: 10.1016/j.biomaterials.2021.121013. Online ahead of print.ABSTRACTThe transcription factor NF-κB and its signaling cascade both play key roles in all inflammatory processes. The most critical member of the NF-κB transcription factor family is p65. We investigated the role of cationic silica-coated calcium phosphate nanoparticles (spherical, diameter by SEM 50-60 nm; zeta potential about +26 mV; stabilized by polyethyleneimine) carrying encapsulated siRNA against NF-κB p65 and their influence on inflamed cells. The nanoparticles were taken up by cells of the blood compartment inv...
Source: Biomaterials - July 12, 2021 Category: Materials Science Authors: Nataniel Bia łas Elena K M üller Matthias Epple Ingrid Hilger Source Type: research

Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles inhibits triple-negative breast cancer progression and metastasis
Biomaterials. 2021 Jun 24;275:120988. doi: 10.1016/j.biomaterials.2021.120988. Online ahead of print.ABSTRACTPD-L1/PD-1 blockade therapy shows durable responses to triple-negative breast cancer (TNBC), but the response rate is low. CD155 promotes tumor metastasis intrinsically and modulates the immune response extrinsically as the ligand of DNAM-1 (costimulatory receptor) and TIGIT/CD96 (coinhibitory receptors). Herein, we verified that TNBC cells coexpressed PD-L1 and CD155. By examining the receptors of PD-L1 and CD155 on TNBC tumor-infiltrating lymphocytes (TILs) over time, we observed that PD-1 and DNAM-1 were upregula...
Source: Biomaterials - June 29, 2021 Category: Materials Science Authors: Chuanrong Chen Qianqian Guo Hao Fu Jian Yu Liting Wang Ying Sun Jiali Zhang Yourong Duan Source Type: research

Rac1-GTPase regulates compression-induced actin protrusions (CAPs) of mesenchymal stem cells in 3D collagen micro-tissues
This study delineates the mechanism of compression-induced cytoskeleton reorganization, contributing to rationalizing mechanical loading regimes for functional tissue engineering.PMID:33933985 | DOI:10.1016/j.biomaterials.2021.120829
Source: Biomaterials - May 2, 2021 Category: Materials Science Authors: Vincent Kwok Lim Lam Johnny Yu Hin Wong Sing Yian Chew Barbara Pui Chan Source Type: research

PEGylation of poly(amine-co-ester) polyplexes for tunable gene delivery
Biomaterials. 2021 Mar 24;272:120780. doi: 10.1016/j.biomaterials.2021.120780. Online ahead of print.ABSTRACTThere is growing interest in PEGylation of cationic polymeric vehicles for gene delivery in order to improve vehicle stability and reduce toxicity, but little is known about the effects of PEG coatings on transfection. We used a polymer from the poly(amine-co-ester) (PACE) family blended with PEG-conjugated PACE at different ratios in order to explore the effects of polyplex PEGylation on the transfection efficiency of plasmid DNA, mRNA, and siRNA in vitro and mRNA in vivo. We discovered that concentrations of PACE-...
Source: Biomaterials - April 4, 2021 Category: Materials Science Authors: Molly K Grun Alexandra Suberi Kwangsoo Shin Teresa Lee Victoria Gomerdinger Zoe M Moscato Alexandra S Piotrowski-Daspit W Mark Saltzman Source Type: research