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Source: Biomaterials
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Total 156 results found since Jan 2013.
Synergetic regulation of kupffer cells, extracellular matrix and hepatic stellate cells with versatile CXCR4-inhibiting nanocomplex for magnified therapy in liver fibrosis
Biomaterials. 2022 Mar 29;284:121492. doi: 10.1016/j.biomaterials.2022.121492. Online ahead of print.ABSTRACTHepatic stellate cell (HSC)-targeted delivery is an attractive strategy for liver fibrosis therapy, but the efficacy is hampered by poor delivery of nanomaterials and complicated microenvironments of the fibrotic liver. Here, we report a versatile CXCR4-inhibiting nanocomplex composed of polymeric CXCR4 antagonism (PAMD, PA), CLD (clodronate) and siPAI-1 (siRNA of plasminogen activator inhibitor-1) that surmounts multiple barriers to improve the outcome by co-regulating Kupffer cells (KCs), extracellular matrix (ECM...
Source: Biomaterials - April 8, 2022 Category: Materials Science Authors: Pengkai Wu Xinping Luo Meiling Sun Beicheng Sun Minjie Sun Source Type: research
ATP-exhausted nanocomplexes for intratumoral metabolic intervention and photoimmunotherapy
Biomaterials. 2022 Mar 29;284:121503. doi: 10.1016/j.biomaterials.2022.121503. Online ahead of print.ABSTRACTTumor cells reprogram the metabolic pathways to acquire abundant nutrients and sustain malignant proliferation. This fierce metabolic competition in tumor ecosystem has been uncovered to be associated with tumor microenvironmental immunosuppression. Here we develop an adenosine triphosphate (ATP)-exhausted nanocomplex (IR@ZIF-RGD) to intervene in tumor energy metabolism and regulate tumor immune microenvironment. IR@ZIF-RGD could effectively deplete intracellular ATP and inhibit ATP synthesis by ATP-responsive ZIF-9...
Source: Biomaterials - April 3, 2022 Category: Materials Science Authors: Mian Yu Weiwei Zeng Yaqi Ouyang Shu Liang Yunfei Yi Huisong Hao Jiayin Yu Yang Liu Yichu Nie Tianqi Wang Yang Deng Meiying Wu Source Type: research
Using computational methods to design patient-specific electrospun cardiac patches for pediatric heart failure
Biomaterials. 2022 Feb 18;283:121421. doi: 10.1016/j.biomaterials.2022.121421. Online ahead of print.ABSTRACTAutologous cardiac cell therapy is a promising treatment for combating the right ventricular heart failure (RVHF) that can occur in patients with congenital heart disease (CHD). However, autologous cell therapies suffer from low cell retention following injection and patient-to-patient variability in cell quality. Here, we demonstrate how computational methods can be used to identify mechanisms of cardiac-derived c-Kit+ cell (CPC) reparative capacity and how biomaterials can be designed to improve cardiac patch perf...
Source: Biomaterials - February 26, 2022 Category: Materials Science Authors: Benjamin W Streeter Milton E Brown Preety Shakya Hyun-Ji Park Jichuan Qiu Younan Xia Michael E Davis Source Type: research
Facile one-step synthesis of NIR-Responsive siRNA-Inorganic hybrid nanoplatform for imaging-guided photothermal and gene synergistic therapy
Biomaterials. 2022 Jan 31;282:121404. doi: 10.1016/j.biomaterials.2022.121404. Online ahead of print.ABSTRACTDiagnosis-guided synergistic treatment based on innovative nanomaterials is of great significance for the development of anti-cancer therapies. However, the low delivery efficiency of therapeutic gene and the inability to trigger release on demand are still major obstacles impeding its wide application. Herein, we report an ultra-fast one-step method within 2 min to prepare a smart carrier, liposome-coated Prussian blue @ gold nano-flower, which is named LPAR after linking with tumor-targeting peptide. The versatile...
Source: Biomaterials - February 8, 2022 Category: Materials Science Authors: Xiuna Jia Mengmeng Lv Yunwei Fei Qing Dong Hao Wang Qiong Liu Dan Li Jin Wang Erkang Wang Source Type: research
Intracellular Co-delivery of native antibody and siRNA for combination therapy by using biodegradable silica nanocapsules
Biomaterials. 2022 Jan 17;281:121376. doi: 10.1016/j.biomaterials.2022.121376. Online ahead of print.ABSTRACTCombination therapy is a promising strategy for treating multidrug-resistant (MDR) cancers. Macromolecules such as antibodies and RNAs have been successfully used for targeted therapy owing to their high specificity. However, their application as therapeutics remains limited due to membrane impermeability and poor intracellular stability. Designing drug delivery systems capable of co-administering macromolecules is therefore crucial for advancing them as therapeutics for combination therapy. Herein, by using glutath...
Source: Biomaterials - January 22, 2022 Category: Materials Science Authors: Peiyan Yuan Fen Yang Si Si Liew Jiachang Yan Xiao Dong Jinfeng Wang Shubo Du Xin Mao Liqian Gao Shao Q Yao Source Type: research
Versatile fully biodegradable dendritic nanotherapeutics
Biomaterials. 2022 Jan 3;281:121356. doi: 10.1016/j.biomaterials.2021.121356. Online ahead of print.ABSTRACTThe repeated administration of non-degradable dendrimers can lead to toxicity due to their bioaccumulation. Furthermore, in drug delivery applications, carrier stability can result in low biological performance due to insufficient intracellular cargo release. A novel family of versatile, biosafe, water-soluble, and fully biodegradable PEG-dendritic nanosystems is proposed, which overcomes the limitations of the most used dendrimers. Their novelty relies on the full and adjustable degradability thanks to the presence ...
Source: Biomaterials - January 15, 2022 Category: Materials Science Authors: Victoria Leiro Ana Patr ícia Spencer Nat ália Magalhães Ana Paula P êgo Source Type: research
SHMT1 siRNA-Loaded hyperosmotic nanochains for blood-brain/tumor barrier post-transmigration therapy
Biomaterials. 2021 Dec 30;281:121359. doi: 10.1016/j.biomaterials.2021.121359. Online ahead of print.ABSTRACTThe near-perivascular accumulation in solid tumors and short-lived span in circulation, derails even the most competent nanoparticles (NPs) from achieving their maximum therapeutic potential. Moreover, delivering them across the blood brain/tumor barrier (BBB/BTB) is further challenging to sought anticancer effect. To address these key challenges, we designed a linearly aligned nucleic acid-complexed polydixylitol-based polymeric nanochains (X-NCs), with inherent hyperosmotic properties enabling transmigration of th...
Source: Biomaterials - January 8, 2022 Category: Materials Science Authors: Shambhavi Pandey Myung Chul Lee Jae Woon Lim Yun-Hoon Choung Kyoung-Je Jang Sang Bae Park Jae Eun Kim Jong Hoon Chung Pankaj Garg Source Type: research
Exosomes derived from immunogenically dying tumor cells as a versatile tool for vaccination against pancreatic cancer
Biomaterials. 2021 Dec 2;280:121306. doi: 10.1016/j.biomaterials.2021.121306. Online ahead of print.ABSTRACTDespite tremendous progress achieved in immunotherapy, many critical challenges in treating pancreatic ductal adenocarcinoma (PDAC) persist. Considering the poor vascularization of PDAC, after intramuscular administration exosomes can targeted deliver "cargos" to pancreatic tumors and bypass obstructions of the intrinsic overexpressed stroma through lymphatics. Herein, we propose a strategy to derive exosomes from immunogenically dying tumor cells and exploit their properties for several purposes, including antigen p...
Source: Biomaterials - December 24, 2021 Category: Materials Science Authors: Wenxi Zhou Xinli Chen Yu Zhou Si Shi Chen Liang Xianjun Yu Hongyi Chen Qin Guo Yiwen Zhang Peixin Liu Chao Li Yongchao Chu Yifan Luo Yu Wang Zheng Zhou Zhenhao Zhao Qinjun Chen Tao Sun Chen Jiang Source Type: research
Dual targeted delivery of statins and nucleic acids by chitosan-based nanoparticles for enhanced antiatherosclerotic efficacy
Biomaterials. 2021 Dec 15;280:121324. doi: 10.1016/j.biomaterials.2021.121324. Online ahead of print.ABSTRACTCardiovascular disease caused by atherosclerosis is a leading cause of morbidity and mortality worldwide. Owing to the synergistic regulation of cholesterol metabolism and lesion inflammation, the simultaneous administration of statins and nucleic acids is expected to alleviate atherosclerosis. In this work, we prepared atorvastatin- and galactose-modified trimethyl chitosan nanoparticles (GTANPs) with dual targeting to hepatocytes and lesional macrophages for encapsulating Baf60a siRNA (siBaf60a) and anti-miR-33 pD...
Source: Biomaterials - December 21, 2021 Category: Materials Science Authors: Ting Jiang Lu Xu Mengxin Zhao Fei Kong Xinrong Lu Cui Tang Chunhua Yin Source Type: research
