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Source: Biomaterials
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Total 156 results found since Jan 2013.
Synchronous targeted delivery of TGF- β siRNA to stromal and tumor cells elicits robust antitumor immunity against triple-negative breast cancer by comprehensively remodeling the tumor microenvironment
Biomaterials. 2023 Jul 25;301:122253. doi: 10.1016/j.biomaterials.2023.122253. Online ahead of print.ABSTRACTThe poor permeability of therapeutic drugs, limited T-cell infiltration, and strong immunosuppressive tumor microenvironment of triple-negative breast cancer (TNBC) acts as a prominent barrier to the delivery of drugs and immunotherapy including programmed cell death ligand-1 antibody (anti-PD-L1). Transforming growth factor (TGF)-β, an important cytokine produced by cancer-associated fibroblasts (CAFs) and tumor cells contributes to the pathological vasculature, dense tumor stroma and strong immunosuppressive tumo...
Source: Biomaterials - August 3, 2023 Category: Materials Science Authors: Mengmeng Yang Chao Qin Linlin Tao Gang Cheng Jingjing Li Fangnan Lv Nan Yang Zuhang Xing Xinyu Chu Xiaopeng Han Meirong Huo Lifang Yin Source Type: research
Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery
Biomaterials. 2023 May 15;299:122158. doi: 10.1016/j.biomaterials.2023.122158. Online ahead of print.ABSTRACTTherapeutic nucleic acids (TNAs) comprise an alternative to conventional drugs for cancer therapy. Recently, stable nucleic acid lipid particles (SNALPs) have been explored to deliver TNA efficiently and safely both in vitro and in vivo. Small interfering RNA (siRNA) and messenger RNA (mRNA) based drugs have been suggested for a wide range of pathologies, and their respective lipid nanoparticle (LNP) formulations have been optimised using a Design of Experiments (DoE) approach. However, it is uncertain as to whether...
Source: Biomaterials - May 27, 2023 Category: Materials Science Authors: Yue Qin Adam A Walters Nadia Rouatbi Julie Tzu-Wen Wang Hend Mohamed Abdel-Bar Khuloud T Al-Jamal Source Type: research
Retinol-binding protein-hijacking nanopolyplex delivering siRNA to cytoplasm of hepatic stellate cell for liver fibrosis alleviation
This study provides a sophisticated method for HSC-targeting cytoplasmic RNA delivery using endogenous ligand hijacking and dual sensitivity of ROS and cis diol compounds.PMID:37167895 | DOI:10.1016/j.biomaterials.2023.122134
Source: Biomaterials - May 11, 2023 Category: Materials Science Authors: Jinsheng Huang Huiling Huang Yiyao Wang Bin Xu Minzhao Lin Shisong Han Yuanyuan Yuan Yong Wang Xintao Shuai Source Type: research
Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing
Biomaterials. 2023 Mar 28;297:122098. doi: 10.1016/j.biomaterials.2023.122098. Online ahead of print.ABSTRACTGene silencing with siRNA nanoparticles (si-NPs) is promising but still clinically unrealized for inhibition of tumor driver genes. Ternary si-NPs containing siRNA, a single block NP core-forming polymer poly[(2-(dimethylamino)ethyl methacrylate)-co-(butyl methacrylate)] (DMAEMA-co-BMA, 50B), and an NP surface-forming diblock polymer 20 kDa poly(ethylene glycol)-block-50B (20kPEG-50B) have the potential to improve silencing activity in tumors due to the participation of both 50B and 20kPEG-50B in siRNA electrostatic...
Source: Biomaterials - April 9, 2023 Category: Materials Science Authors: Shrusti S Patel Ella N Hoogenboezem Fang Yu Carlisle R DeJulius R Brock Fletcher Alex G Sorets Fiona K Cherry Justin H Lo Mariah G Bezold Nora Francini Richard d'Arcy Jordan E Brasuell Rebecca S Cook Craig L Duvall Source Type: research
Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells
Biomaterials. 2023 Jan 21;294:122016. doi: 10.1016/j.biomaterials.2023.122016. Online ahead of print.ABSTRACTTargeted delivery of oligonucleotides or small molecular drugs to hepatocytes, the liver's parenchymal cells, is challenging without targeting moiety due to the highly efficient mononuclear phagocyte system (MPS) of the liver. The MPS comprises Kupffer cells and specialized sinusoidal endothelial cells, efficiently clearing nanocarriers regardless of their size and surface properties. Physiologically, this non-parenchymal shield protects hepatocytes; however, these local barriers must be overcome for drug delivery. ...
Source: Biomaterials - January 26, 2023 Category: Materials Science Authors: WanLing Foo Zolt án Cseresnyés Carsten R össel Yingfeng Teng Anuradha Ramoji Mingzhe Chi Walter Hauswald Sophie Huschke Stephanie Hoeppener J ürgen Popp Felix H Schacher Marek Sierka Marc Thilo Figge Adrian T Press Michael Bauer Source Type: research
Corrigendum to "Redox-responsive polyprodrug nanoparticles for targeted siRNA delivery and synergistic liver cancer therapy" Biomater. 234 (2020) 119760
Biomaterials. 2022 Dec 14;293:121951. doi: 10.1016/j.biomaterials.2022.121951. Online ahead of print.NO ABSTRACTPMID:36525705 | DOI:10.1016/j.biomaterials.2022.121951
Source: Biomaterials - December 16, 2022 Category: Materials Science Authors: Senlin Li Phei Er Saw Chunhao Lin Yan Nie Wei Tao Omid C Farokhzad Lei Zhang Xiaoding Xu Source Type: research
Self-amplified ROS production from fatty acid oxidation enhanced tumor immunotherapy by atorvastatin/PD-L1 siRNA lipopeptide nanoplexes
Biomaterials. 2022 Nov 3;291:121902. doi: 10.1016/j.biomaterials.2022.121902. Online ahead of print.ABSTRACTDespite the important role of reactive oxygen species (ROS) in battling cancer, ROS production with current approaches has been severely limited by the deficiency of oxy-substrates in tumor microenvironment. Herein, an atorvastatin (Ato)-catalytic self-amplified approach was utilized for sustainable ROS production and enhancing anti-tumor efficacy of PD-L1 silencing. A C18-pArg8-ss-pHis10 lipopeptide based self-assembled nanoplexes was developed to co-encapsulate AMP-activated protein kinase (AMPK) activator of Ato a...
Source: Biomaterials - November 13, 2022 Category: Materials Science Authors: Yan Gao Zilin Song Li Jia Yi Tang Chengcheng Wang Xiuli Zhao Haiyang Hu Dawei Chen Mingxi Qiao Source Type: research
