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Synchronous targeted delivery of TGF- β siRNA to stromal and tumor cells elicits robust antitumor immunity against triple-negative breast cancer by comprehensively remodeling the tumor microenvironment
Biomaterials. 2023 Jul 25;301:122253. doi: 10.1016/j.biomaterials.2023.122253. Online ahead of print.ABSTRACTThe poor permeability of therapeutic drugs, limited T-cell infiltration, and strong immunosuppressive tumor microenvironment of triple-negative breast cancer (TNBC) acts as a prominent barrier to the delivery of drugs and immunotherapy including programmed cell death ligand-1 antibody (anti-PD-L1). Transforming growth factor (TGF)-β, an important cytokine produced by cancer-associated fibroblasts (CAFs) and tumor cells contributes to the pathological vasculature, dense tumor stroma and strong immunosuppressive tumo...
Source: Biomaterials - August 3, 2023 Category: Materials Science Authors: Mengmeng Yang Chao Qin Linlin Tao Gang Cheng Jingjing Li Fangnan Lv Nan Yang Zuhang Xing Xinyu Chu Xiaopeng Han Meirong Huo Lifang Yin Source Type: research

Delivery of small interfering RNA against Nogo-B receptor via tumor-acidity responsive nanoparticles for tumor vessel normalization and metastasis suppression.
This study demonstrated that NgBR is a promising therapeutic target in abnormal tumor vasculature and aggressive cancer cells, and the tumor-responsive nanoparticle with the feature of charge transformation offers great potential for tumor-specific delivery of gene therapeutics. PMID: 29803999 [PubMed - as supplied by publisher]
Source: Biomaterials - May 21, 2018 Category: Materials Science Authors: Wang B, Ding Y, Zhao X, Han X, Yang N, Zhang Y, Zhao Y, Zhao X, Taleb M, Miao QR, Nie G Tags: Biomaterials Source Type: research

Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids.
Abstract The poor penetration of nanocarrier-siRNA constructs into tumor tissue is a major hurdle for the in vivo efficacy of siRNA therapeutics, where the ability of the constructs to permeate the 3D multicellular matrix is determined by their physicochemical properties. Herein, we optimized the use of soft glycogen nanoparticles for the engineering of glycogen-siRNA constructs that can efficiently penetrate multicellular tumor spheroids and exert a significant gene silencing effect. Glycogen nanoparticles from different bio-sources and with different structural features were investigated. We show that larger gl...
Source: Biomaterials - May 20, 2018 Category: Materials Science Authors: Wojnilowicz M, Besford QA, Wu YL, Loh XJ, Braunger JA, Glab A, Cortez-Jugo C, Caruso F, Cavalieri F Tags: Biomaterials Source Type: research