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MicroRNA-378a-5p Targets Cyclin G2 to Inhibit Fusion and Differentiation in BeWo Cells.
Abstract MicroRNAs are expressed abundantly in the placenta throughout pregnancy. We have previously reported that miR-378a-5p promoted trophoblast migration and invasion. To further understand the role of miR-378a-5p during placental development, we investigated whether it may regulate the differentiation of syncytiotrophoblast (STB). Using a choriocarcinoma cell line, BeWo, we found that miR-378a-5p was down-regulated during Forskolin-induced STB differentiation. Transfection of a miR-378a-5p mimic into BeWo cells decreased the formation of multinucleated STB, increased E-cadherin, and decreased the expression l...
Source: Biology of Reproduction - August 13, 2014 Category: Reproduction Medicine Authors: Nadeem U, Ye G, Salem M, Peng C Tags: Biol Reprod Source Type: research