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Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride.
Abstract In a previous work we have shown that exposure to aluminum (Al) chloride (AlCl3) enhanced the neurotoxicity of the amyloid beta25-35 fragment (Abeta25-35) in neuroblastoma cells and affected the expression of Alzheimer's disease (AD)-related genes. Caffein, a compound endowed with beneficial effects against AD, exerts neuroprotection primarily through its antagonist activity on A2A adenosine receptors (A2AR), although it also inhibits A1Rs with similar potency. Still, studies on the specific involvement of these receptors in neuroprotection in a model of combined neurotoxicity (Abeta25-35+AlCl3) are missi...
Source: The International Journal of Biochemistry and Cell Biology - July 21, 2014 Category: Biochemistry Authors: Giunta S, Andriolo V, Castorina A Tags: Int J Biochem Cell Biol Source Type: research

NBPF is a potential DNA-binding transcription factor that is directly regulated by NF-κB.
In this study, the genes of NBPF family were found to be densely covered by many high-confidence ChIP-Seq peaks of NF-κB. The expressions of NBPF genes were thus deduced to be regulated by this transcription factor. The activities of NF-κB in HeLa, HepG2 and ECa109 cells were then manipulated with NF-κB activator (TNFα) and inhibitors (BAY11-7082 or p65 siRNA), and the expressions of NBPF genes in these cells were checked. As result, it was found that the expressions of NBPF genes were regulated by NF-κB in HeLa and HepG2 cells. Therefore, the genes of NBPF family were identified as new bona fide direct target genes o...
Source: The International Journal of Biochemistry and Cell Biology - August 9, 2013 Category: Biochemistry Authors: Zhou F, Xing Y, Xu X, Yang Y, Zhang J, Ma Z, Wang J Tags: Int J Biochem Cell Biol Source Type: research