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Source: Free Radical Biology and Medicine

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Total 199 results found since Jan 2013.

C-C Motif Ligand 8 promotes atherosclerosis via NADPH Oxidase 2/Reactive Oxygen Species-induced endothelial permeability Increase
This study might contribute to a deeper understanding of the connection between chemokines and atherosclerosis.PMID:33741452 | DOI:10.1016/j.freeradbiomed.2021.02.022
Source: Free Radical Biology and Medicine - March 20, 2021 Category: Biology Authors: Song Xue Hanfei Tang Gefei Zhao Chao Fang Yang Shen Dong Yan Ye Yuan Weiguo Fu Zhenyu Shi Xiao Tang Daqiao Guo Source Type: research

The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy.
Abstract Diabetic Retinopathy (DR) is a major cause of visual dysfunction, yet much remains unknown regarding the specific molecular events that contribute to diabetes-induced retinal pathophysiology. Herein, we review the impact of oxidative stress on DR, and explore evidence that supports a key role for the stress response protein regulated in development and DNA damage (REDD1) in the development of diabetes-induced oxidative stress and function defects in vision. It is well established that REDD1 mediates the cellular response to a number of diverse stressors through repression of the central metabolic regulato...
Source: Free Radical Biology and Medicine - January 29, 2021 Category: Biology Authors: Miller WP, Sunilkumar S, Dennis MD Tags: Free Radic Biol Med Source Type: research

LRRC8A contributes to angiotensin II-induced cardiac hypertrophy by interacting with NADPH oxidases via the C-terminal leucine-rich repeat domain.
Abstract Cardiac hypertrophy, an important cause of heart failure, is characterized by an increase in heart weight, the ventricular wall, and cardiomyocyte volume. The volume regulatory anion channel (VRAC) is an important regulator of cell volume. However, its role in cardiac hypertrophy remains unclear. The purpose of this study was to investigate the effect of leucine-rich repeat-containing 8A (LRRC8A), an essential component of the VRAC, on angiotensin II (AngII)-induced cardiac hypertrophy. Our results showed that LRRC8A expression, NADPH oxidase activity, and reactive oxygen species (ROS) production were inc...
Source: Free Radical Biology and Medicine - January 27, 2021 Category: Biology Authors: Huo C, Liu Y, Li X, Xu R, Jia X, Hou L, Wang X Tags: Free Radic Biol Med Source Type: research

NQO1 mediates the anti-inflammatory effects of nootkatone in lipopolysaccharide-induced neuroinflammation by modulating the AMPK signaling pathway.
Abstract Neuroinflammation and oxidative stress play key roles in the progression of neurodegenerative diseases. Thus, the use of potent anti-inflammatory/antioxidant agents has been suggested as a promising therapeutic strategy for neurodegenerative diseases. In the present study, we investigated the anti-inflammatory and antioxidant effects of nootkatone (NKT), a sesquiterpenoid compound isolated from grapefruit, in in vitro and in vivo models of neuroinflammation. In lipopolysaccharide (LPS)-stimulated BV2 microglial cells, NKT inhibited the expression of iNOS, COX-2, and pro-inflammatory cytokines, and increas...
Source: Free Radical Biology and Medicine - January 15, 2021 Category: Biology Authors: Park JE, Park JS, Leem YH, Kim DY, Kim HS Tags: Free Radic Biol Med Source Type: research

NOD1 activation induces oxidative stress via NOX1/4 in adipocytes.
Abstract Activation of innate immune components promotes cell autonomous inflammation in adipocytes. Oxidative stress links pattern recognition receptor-mediated detection of inflammatory ligands and the immune response. Reactive oxygen species (ROS) may mediate the effect of nucleotide-binding oligomerization domain protein-1 (NOD1) activation on inflammation in adipocytes. Here, we define the potential role of NADPH oxidase (NOX)-derived ROS in NOD1-mediated inflammatory response in adipocytes. Differentiated 3T3-L1 adipocytes were treated with NOD1 activating ligand D-gamma-Glu-meso-diaminopimelic acid (iE-DAP)...
Source: Free Radical Biology and Medicine - December 3, 2020 Category: Biology Authors: Sharma A, Singh S, Ahmad S, Gulzar F, Schertzer JD, Tamrakar AK Tags: Free Radic Biol Med Source Type: research

Up-regulation of thioredoxin system by puerarin inhibits lipid uptake in macrophages.
In this study, we investigated the effects of puerarin on lipid uptake and explored the underlying molecular regulation. We found puerarin up-regulated thioredoxin-1 (Trx1) and Trx reductase-1 (TrxR1) expression; it increased TrxR1 activity, cellular thiols contents and decreased oxidized form of Trx1, thus inhibiting cellular ROS generation. Confocal microscope and flow cytometry analysis showed fluorescence labeled Dil-oxLDL uptake was dramatically inhibited by puerarin in RAW264.7 cells as well as in primary bone marrow derived macrophages and peritoneal macrophages. The effects were reversed when Trx1 was inhibited by ...
Source: Free Radical Biology and Medicine - November 23, 2020 Category: Biology Authors: Li W, Xu X, Dong D, Lei T, Ou H Tags: Free Radic Biol Med Source Type: research

Angelica dahurica promoted angiogenesis and accelerated wound healing in db/db mice via the HIF-1 α/PDGF-β signaling pathway.
In this study, we found that Angelica dahurica (A. dahurica) stimulated angiogenesis and benefited wound healing in genetic mouse models of diabetes. In HUVECs, A. dahurica promoted cell proliferation and tube formation, which was accompanied by increased nuclear translocation of HIF-1α under hypoxic conditions and led to elevated PDGF-β protein expression. A. dahurica activated the PI3K/AKT signaling pathway in human umbilical vein endothelial cells (HUVECs), which was abrogated by the PI3K inhibitor LY294002. Furthermore, the cellular expression of PDGF-β decreased significantly after treatment with a HIF-1α-siRNA, a...
Source: Free Radical Biology and Medicine - August 23, 2020 Category: Biology Authors: Guo J, Hu Z, Yan F, Lei S, Li T, Li X, Xu C, Sun B, Pan C, Chen L Tags: Free Radic Biol Med Source Type: research

Down regulation of glutathione and glutamate cysteine ligase in the inflammatory response of macrophages.
In conclusion, these data suggest that GCLC down-regulation in the inflammatory response of macrophages is mediated through both increased mRNA decay and caspase-5-mediated GCLC protein degradation, and γ-GC is an efficient agent to restore GSH and regulate the inflammatory response. PMID: 32682927 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - July 15, 2020 Category: Biology Authors: Zhang H, Zhang SJ, Lyn N, Florentino A, Li A, Davies KJA, Forman HJ Tags: Free Radic Biol Med Source Type: research

The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells.
In conclusion, benzbromarone increases mitochondrial O2•- accumulation and activates the NRF2 signaling pathway in HepG2 cells, thereby strengthening the cytosolic and mitochondrial antioxidative defense. Impaired antioxidative defense may represent a risk factor for benzbromarone-induced hepatotoxicity. PMID: 32198009 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - March 16, 2020 Category: Biology Authors: Roos NJ, Duthaler U, Bouitbir J, Krähenbühl S Tags: Free Radic Biol Med Source Type: research

Regulation of mitochondrial cristae remodelling by acetylcholine alleviates palmitate-induced cardiomyocyte hypertrophy.
This study investigated the role of cristae remodelling in palmitate (PA)-induced neonatal rat cardiomyocyte hypertrophy and explored the beneficial effects of ACh. We found loose, fragmented and even lysed cristae in PA-treated neonatal cardiomyocytes along with declines in mitochondrial network and complex expression and overproduction of mitochondrial reactive oxygen species (ROS); these changes ultimately resulted in increased myocardial size. Overexpression of mitofilin by adenoviral infection partly improved cristae shape, mitochondrial network, and ATP content and attenuated cell hypertrophy. Interestingly, siRNA-me...
Source: Free Radical Biology and Medicine - September 21, 2019 Category: Biology Authors: Xue RQ, Zhao M, Wu Q, Yang S, Cui YL, Yu XJ, Liu JK, Zang WJ Tags: Free Radic Biol Med Source Type: research

Free heme regulates placenta growth factor through NRF2-antioxidant response signaling.
Abstract Free heme activates erythroblasts to express and secrete Placenta Growth Factor (PlGF), an angiogenic peptide of the VEGF family. High circulating levels of PlGF have been associated in experimental animals and in patients with sickle cell disease with echocardiographic markers of pulmonary hypertension, a life-limiting complication associated with more intense hemolysis. We now show that the mechanism of heme regulation of PlGF requires the contribution of the key antioxidant response regulator NRF2. Mimicking the effect of heme, the NRF2 agonist sulforaphane stimulates the PlGF transcript level nearly 3...
Source: Free Radical Biology and Medicine - August 9, 2019 Category: Biology Authors: Kapetanaki MG, Gbotosho OT, Sharma D, Weidert F, Ofori-Acquah SF, Kato GJ Tags: Free Radic Biol Med Source Type: research

Oxidized base 8-oxoguanine, a product of DNA repair processes, contributes to dendritic cell activation.
Abstract A growing body of evidence suggests that elevated levels of reactive oxygen species (ROS) in the airways caused by exposure to gas phase pollutants or particulate matter are able to activate dendritic cells (DCs); however, the exact mechanisms are still unclear. When present in excess, ROS can modify macromolecules including DNA. One of the most abundant DNA base lesions is 7,8-dihydro-8-oxoguanine (8-oxoG), which is repaired by the 8-oxoguanine DNA glycosylase 1 (OGG1)-initiated base excision repair (BER) pathway. Studies have also demonstrated that in addition to its role in repairing oxidized purines, ...
Source: Free Radical Biology and Medicine - August 9, 2019 Category: Biology Authors: Pázmándi K, Sütő M, Fekete T, Varga A, Boldizsár E, Boldogh I, Bácsi A Tags: Free Radic Biol Med Source Type: research

Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury.
Conclusions: TL potentiate ROS by mitochondria which activate mitochondrial oxidative stress, decrease ATP production, increase mitochondrial proton leak and glycolysis rate, and mitochondria DNA damage. Additionally, CPT1A1 siRNA knockdown suppresses oxidative stress and prevents mitochondrial dysfunction and vascular inflammation in TL treated HBMECs. TL activates ATF3-MAPKinase, TNF, and NRF2 signaling pathways. Furthermore, the NRF2 signaling pathway which is upstream of the ATF3-MAPKinase signaling pathway, is also regulated by the mitochondrial oxidative stress. We are the first to report differential inflammatory ch...
Source: Free Radical Biology and Medicine - July 25, 2019 Category: Biology Authors: Nyunt T, Britton M, Wanichthanarak K, Budamagunta M, Voss JC, Wilson DW, Rutledge JC, Aung HH Tags: Free Radic Biol Med Source Type: research

S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
This study provides insights on the potential of CySSPe as an onion-derived dietary agent that modulates redox homeostasis and combats oxidative stress. PMID: 31349040 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - July 22, 2019 Category: Biology Authors: Tocmo R, Parkin K Tags: Free Radic Biol Med Source Type: research