Down regulation of glutathione and glutamate cysteine ligase in the inflammatory response of macrophages.

In conclusion, these data suggest that GCLC down-regulation in the inflammatory response of macrophages is mediated through both increased mRNA decay and caspase-5-mediated GCLC protein degradation, and γ-GC is an efficient agent to restore GSH and regulate the inflammatory response.
PMID: 32682927 [PubMed - as supplied by publisher]

Source: Free Radical Biology and Medicine - July 15, 2020 Category: Biology Authors: Zhang H, Zhang SJ, Lyn N, Florentino A, Li A, Davies KJA, Forman HJ Tags: Free Radic Biol Med Source Type: research